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- Title
Oroxylin A Inhibits Allergic Airway Inflammation in Ovalbumin (OVA)-Induced Asthma Murine Model.
- Authors
Zhou, De-Gang; Diao, Bao-Zhong; Zhou, Wen; Feng, Jia-Long
- Abstract
Oroxylin A, a natural flavonoid isolated from the medicinal herb Scutellaria baicalensis Georgi, has been reported to have anti-inflammatory property. In this study, we aimed to investigate the protective effects and mechanism of oroxylin A on allergic inflammation in OVA-induced asthma murine model. BABL/c mice were sensitized and airway-challenged with OVA to induce asthma. Oroxylin A (15, 30, and 60 mg/kg) was administered by oral gavage 1 h before the OVA treatment on day 21 to 23. The results showed that oroxylin A attenuated OVA-induced lung histopathologic changes, airway hyperresponsiveness, and the number of inflammatory cells. Oroxylin A also inhibited the levels of IL-4, IL-5, IL-13, and OVA-specific IgE in BALF. Furthermore, oroxylin A significantly inhibited OVA-induced NF-κB activation. In conclusion, these results suggested that oroxylin A inhibited airway inflammation in OVA-induced asthma murine model by inhibiting NF-κB activation. These results suggested that oroxylin A was a potential therapeutic drug for treating allergic asthma.
- Subjects
FLAVONOIDS; CHINESE skullcap; HERBAL medicine; OVALBUMINS; ANTI-inflammatory agents; ASTHMA; NF-kappa B; RESPIRATORY allergy
- Publication
Inflammation, 2016, Vol 39, Issue 2, p867
- ISSN
0360-3997
- Publication type
Article
- DOI
10.1007/s10753-016-0317-3