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- Title
DNA Methylation of BDNF and RASA2 Genes Is Associated With Cognitive Function in Postmenopausal Women With Breast Cancer.
- Authors
Myeong-ga Cho; Sereika, Susan M.; Cummings, Meredith H.; Erickson, Kirk I.; Bender, Catherine M.; Conley, Yvette P.
- Abstract
OBJECTIVES: To determine associations among DNA methylation of brain-derived neurotrophic factor (BDNF) and RAS p21 protein activator 2 (RASA2) genes with processing speed and perceived cognitive function. SAMPLE & SETTING: This was a cross-sectional, secondary analysis of baseline data from a randomized controlled trial, the Exercise Program in Cancer and Cognition Study. METHODS & VARIABLES: Data included M values for DNA methylation of the BDNF and RASA2 genes; processing speed, objectively measured using the Grooved Pegboard and Digit Vigilance Test scores; and perceived cognitive function, self-reported using the Patient Assessment of Own Functioning Inventory. Regression analysis was conducted. RESULTS: Greater methylation of cg21291635 of the BDNF gene (p = 0.01) and cg20247102 of the RASA2 gene (p = 0.013) were associated with poorer processing speed, whereas greater methylation of cg20108357 of the BDNF gene (p < 0.001) and cg00567892 of the RASA2 gene (p = 0.019) were associated with better perceived cognitive function. IMPLICATIONS FOR NURSING: Gene methylation variations were demonstrated, suggesting the genes' potential roles and two possible distinct mechanisms of cognitive function in cancer.
- Subjects
BREAST tumor prevention; CROSS-sectional method; MULTITRAIT multimethod techniques; PEARSON correlation (Statistics); SECONDARY analysis; EXECUTIVE function; BREAST tumors; QUESTIONNAIRES; COGNITIVE processing speed; MULTIPLE regression analysis; POSTMENOPAUSE; PSYCHOLOGY of women; DNA methylation; CANCER chemotherapy; BRAIN-derived neurotrophic factor; ONCOGENES; RESEARCH methodology; RESEARCH; COGNITION disorders; DATA analysis software; COGNITION; REGRESSION analysis
- Publication
Oncology Nursing Forum, 2024, Vol 51, Issue 4, p349
- ISSN
0190-535X
- Publication type
Article
- DOI
10.1188/24.ONF.404-416