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- Title
Detection of a Novel gyrB Mutation Associated With Fluoroquinolone-Nonsusceptible Salmonella enterica serovar Typhimurium Isolated From a Bloodstream Infection in Ghana.
- Authors
Al-Emran, Hassan M.; Heisig, Anke; Dekker, Denise; Adu-Sarkodie, Yaw; Cruz Espinoza, Ligia Maria; Panzner, Ursula; von Kalckreuth, Vera; Marks, Florian; Se Eun Park; Sarpong, Nimako; May, Jürgen; Heisig, Peter
- Abstract
A multidrug-resistant Salmonella enterica serovar Typhimurium with reduced susceptibility to ciprofloxacin was isolated from the blood of a hospitalized child in Ghana. DNA sequencing identified a novel gyrB mutation at codon 466 (Glu466Asp). An increase in fluoroquinolone susceptibility after the introduction of a wild-type gyrB+ allele demonstrated that the gyrB466 mutation had a direct effect on fluoroquinolone susceptibility.
- Publication
Clinical Infectious Diseases, 2016, Vol 62, pS47
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/civ790