We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
A Pill for HIV Prevention: Déjà Vu All Over Again?
- Authors
Myers, Julie E.; Sepkowitz, Kent A.
- Abstract
Recent FDA approval of tenofovir-emtricitabine for HIV prevention has led to concern about implementation of this approach. We review the social and medical history of the oral contraceptive pill, which has many parallels with the current debate about pre-exposure prophylaxis.Recent FDA approval of tenofovir-emtricitabine for prevention of human immunodeficiency virus (HIV) as a form of pre-exposure prophylaxis (PrEP) has led to concern about implementation of this strategy. Fifty years ago, a very similar national and international debate occurred when the oral contraceptive pill (“the Pill” or “OCP”) was approved. Contentious issues included OCP safety, cost, and the potential impact on sexual behavior—many of the same concerns being voiced currently about PrEP. In this article, we review the social and medical history of OCP, drawing parallels with the current PrEP debate. We also explore the key areas where PrEP differs from its forbear: lower efficacy, presence of drug resistance, and a more circumscribed (and marginalized) target population. A thoughtful approach to PrEP implementation, bearing in mind the historical insights gained from the 1960s, might serve as well as we begin this new chapter in the control of the HIV epidemic.
- Subjects
HIV prevention; DRUG approval; TENOFOVIR; EMTRICITABINE; ORAL contraceptives; BIRTH control; DRUG resistance
- Publication
Clinical Infectious Diseases, 2013, Vol 56, Issue 11, p1604
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/cit085