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- Title
SERUM OMENTIN-1 LEVELS AND ENDOTHELIAL DYSFUNCTION IN OBESITY.
- Authors
Çimen, A. R.; Cerit, E. T.; Iyidir, O. T.; Karakus, R.; Uyar, B. B.; Toruner, F. B.; Cakir, N.; Arslan, M.
- Abstract
Introduction. Our aim was to investigate the relationship between serum omentin-1 levels and endothelial dysfunction in obese patients. Material and Methods. We evaluated 50 obese patients, and age/gender matched 45 healthy non-obese subjects as controls. Oral glucose tolerance test, lipid parameters, uric acid levels, homeostatic model assessmentinsulin resistance (HOMA-IR) index, serum omentin-1 levels and flow mediated dilatation (FMD) % were measured in all subjects. Body compositions were analyzed with bioelectrical impedance method using a Tanita Body Composition Analyzer and ViScan. Results. Serum omentin-1 levels were found significantly lower in obese population compared to the control subjects. FMD response was significantly decreased in obese population. There was a significant positive correlation between serum omentin-1 levels and FMD response (r=0.359, p<0.001). Serum omentin-1 levels were negatively correlated with body mass index (BMI), waist circumference, total fat percentage, visceral fat, fasting insulin and HOMA-IR index. Conclusion. Lower serum omentin-1 levels and decreased FMD response may be an early marker of endothelial dysfunction in obese patients.
- Subjects
ENDOTHELIUM diseases; OVERWEIGHT persons; GLUCOSE tolerance tests; HUMAN body composition; URIC acid; DISEASES
- Publication
Acta Endocrinologica (1841-0987), 2017, Vol 13, Issue 2, p138
- ISSN
1841-0987
- Publication type
Article
- DOI
10.4183/aeb.2017.138