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- Title
A randomized clinical trial of oral ursodeoxycholic acid in obstructive jaundice.
- Authors
Thompson, J. N.; Cohen, J.; Blenkharn, J. I.; McConnell, J. S.; Barr, J.; Blumgart, L. H.
- Abstract
Forty patients with obstructive jaundice (bilirubin > 100 μmol/l) were entered into a randomized trial of oral ursodeoxycholic acid for 48 h before surgery versus no additional therapy. Pre-operative venous and operative portal total bile salt concentrations were higher in the bile salt treated patients ( P < 0.001). Portal endotoxaemia during operation was reduced in ursodeoxycholic acid treated patients ( P < 0.05). There was no significant difference in systemic venous endotoxaemia, renal function or postoperative morbidity or mortality. This study suggests pre-operative oral bile salt therapy may be of no clinical benefit in patients with obstructive jaundice.
- Publication
British Journal of Surgery, 1986, Vol 73, Issue 8, p634
- ISSN
0007-1323
- Publication type
Article
- DOI
10.1002/bjs.1800730819