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- Title
Deficiency Stimulates Thermogenic Beige Adipocytes Through Activation.
- Authors
Yun Kyung Lee; Jee Hyung Sohn; Ji Seul Han; Yoon Jeong Park; Yong Geun Jeon; Yul Ji; Dalen, Knut Tomas; Sztalryd, Carole; Kimmel, Alan R.; Jae Bum Kim; Lee, Yun Kyung; Sohn, Jee Hyung; Han, Ji Seul; Park, Yoon Jeong; Jeon, Yong Geun; Ji, Yul; Kim, Jae Bum
- Abstract
Beige adipocytes can dissipate energy as heat. Elaborate communication between metabolism and gene expression is important in the regulation of beige adipocytes. Although lipid droplet (LD) binding proteins play important roles in adipose tissue biology, it remains unknown whether perilipin 3 (Plin3) is involved in the regulation of beige adipocyte formation and thermogenic activities. In this study, we demonstrate that Plin3 ablation stimulates beige adipocytes and thermogenic gene expression in inguinal white adipose tissue (iWAT). Compared with wild-type mice, Plin3 knockout mice were cold tolerant and displayed enhanced basal and stimulated lipolysis in iWAT, inducing peroxisome proliferator-activated receptor α (PPARα) activation. In adipocytes, Plin3 deficiency promoted PPARα target gene and uncoupling protein 1 expression and multilocular LD formation upon cold stimulus. Moreover, fibroblast growth factor 21 expression and secretion were upregulated, which was attributable to activated PPARα in Plin3-deficient adipocytes. These data suggest that Plin3 acts as an intrinsic protective factor preventing futile beige adipocyte formation by limiting lipid metabolism and thermogenic gene expression.
- Subjects
FAT cells; METABOLISM; GENE expression; PERILIPIN; PEROXISOME proliferator-activated receptors
- Publication
Diabetes, 2018, Vol 67, Issue 5, p791
- ISSN
0012-1797
- Publication type
journal article
- DOI
10.2337/db17-0983