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- Title
Immune System Involvement in Diabetes Susceptibility of NOD. ABH.Idd21.1 Mice.
- Authors
Hook, Sarah; Phipps-Green, Amanda; Hollis-Moffat, Jade; Merriman, Tony
- Abstract
It has been previously demonstrated that the Type I diabetes locus Idd21.1 on mouse chromosome 18 co-localises to Iddm3 in rat and IDDM6 in human. This is the first non-MHC autoimmune diabetes locus shown to be orthologous in these three species. Congenic NOD.ABH.Idd21.1 mice that contain the Idd21.1 locus from diabetes resistance ABH mice display a significantly lower incidence of diabetes compared to the parental NOD strain (52% and 85% incidence, respectively, P<0.0001). Adoptive transfer experiments involving the transfer of splenocytes from NOD or NOD.ABH.Idd21.1 into NOD.SCID or NOD.SCID.ABH.Idd21.1 mice confirmed that the reduced diabetes incidence of the ABH.Idd21.1 mice was mediated at least in part by the immune system. The immune system of pre-diabetic NOD and NOD.Idd21.1 mice was then phenotyped in order to determine if any abnormalities could be detected before the onset of disease. NOD.ABH.Idd21.1 congenic mice appeared to have similar numbers lymphocytes and dendritic cells as compared to NOD mice however the cells appeared to be less reactive.
- Subjects
IMMUNE system; DIABETES; DISEASE susceptibility; AUTOIMMUNE diseases; LYMPHOCYTES; DENDRITIC cells
- Publication
Diabetes, 2007, Vol 56, pA319
- ISSN
0012-1797
- Publication type
Article