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- Title
Cerebrospinal Fluid Alpha-Synuclein Improves the Differentiation between Dementia with Lewy Bodies and Alzheimer's Disease in Clinical Practice.
- Authors
Lilamand, Matthieu; Clery, Josué; Vrillon, Agathe; Mouton-Liger, François; Cognat, Emmanuel; Gaubert, Sinead; Hourregue, Claire; Martinet, Matthieu; Dumurgier, Julien; Hugon, Jacques; Bouaziz-Amar, Elodie; Paquet, Claire
- Abstract
Background: Alpha-synuclein, abnormally aggregated in Dementia with Lewy Bodies (DLB), could represent a potential biomarker to improve the differentiation between DLB and Alzheimer's disease (AD). Our main objective was to compare Cerebrospinal Fluid (CSF) alpha-synuclein levels between patients with DLB, AD and Neurological Control (NC) individuals. Methods: In a monocentric retrospective study, we assessed CSF alpha-synuclein concentration with a validated ELISA kit (ADx EUROIMMUN) in patients with DLB, AD and NC from a tertiary memory clinic. Between-group comparisons were performed, and Receiver Operating Characteristic analysis was used to identify the best CSF alpha-synuclein threshold. We examined the associations between CSF alpha-synuclein, other core AD CSF biomarkers and brain MRI characteristics. Results: We included 127 participants (mean age: 69.3 ± 8.1, Men: 41.7%). CSF alpha-synuclein levels were significantly lower in DLB than in AD (1.28 ± 0.52 ng/mL vs. 2.26 ± 0.91 ng/mL, respectively, p < 0.001) without differences due to the stage of cognitive impairment. The best alpha-synuclein threshold was characterized by an Area Under the Curve = 0.85, Sensitivity = 82.0% and Specificity = 76.0%. CSF alpha-synuclein was associated with CSF AT(N) biomarkers positivity (p < 0.01) but not with hippocampal atrophy or white matter lesions. Conclusion: CSF Alpha-synuclein evaluation could help to early differentiate patients with DLB and AD in association with existing biomarkers.
- Subjects
LEWY body dementia; ALZHEIMER'S disease; CEREBROSPINAL fluid examination; ALPHA-synuclein; CEREBROSPINAL fluid; RECEIVER operating characteristic curves; WHITE matter (Nerve tissue)
- Publication
International Journal of Molecular Sciences, 2022, Vol 23, Issue 21, p13488
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms232113488