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- Title
Parkinson's Disease: A Prionopathy?
- Authors
Vascellari, Sarah; Manzin, Aldo
- Abstract
The principal pathogenic event in Parkinson's disease is characterized by the conformational change of α-synuclein, which form pathological aggregates of misfolded proteins, and then accumulate in intraneuronal inclusions causing dopaminergic neuronal loss in specific brain regions. Over the last few years, a revolutionary theory has correlated Parkinson's disease and other neurological disorders with a shared mechanism, which determines α-synuclein aggregates and progresses in the host in a prion-like manner. In this review, the main characteristics shared between α-synuclein and prion protein are compared and the cofactors that influence the remodeling of native protein structures and pathogenetic mechanisms underlying neurodegeneration are discussed.
- Subjects
PARKINSON'S disease; PRION diseases; PROTEIN structure; NEUROLOGICAL disorders; PRIONS
- Publication
International Journal of Molecular Sciences, 2021, Vol 22, Issue 15, p8022
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms22158022