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- Title
Glia and Orofacial Pain: Progress and Future Directions.
- Authors
Ye, Yi; Salvo, Elizabeth; Romero-Reyes, Marcela; Akerman, Simon; Shimizu, Emi; Kobayashi, Yoshifumi; Michot, Benoit; Gibbs, Jennifer; Gasque, Philippe
- Abstract
Orofacial pain is a universal predicament, afflicting millions of individuals worldwide. Research on the molecular mechanisms of orofacial pain has predominately focused on the role of neurons underlying nociception. However, aside from neural mechanisms, non-neuronal cells, such as Schwann cells and satellite ganglion cells in the peripheral nervous system, and microglia and astrocytes in the central nervous system, are important players in both peripheral and central processing of pain in the orofacial region. This review highlights recent molecular and cellular findings of the glia involvement and glia–neuron interactions in four common orofacial pain conditions such as headache, dental pulp injury, temporomandibular joint dysfunction/inflammation, and head and neck cancer. We will discuss the remaining questions and future directions on glial involvement in these four orofacial pain conditions.
- Subjects
OROFACIAL pain; HEAD &; neck cancer; TEMPOROMANDIBULAR disorders; SATELLITE cells; SCHWANN cells; CENTRAL nervous system physiology
- Publication
International Journal of Molecular Sciences, 2021, Vol 22, Issue 10, p5345
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms22105345