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- Title
Lysozyme Fibrils Alter the Mechanism of Insulin Amyloid Aggregation.
- Authors
Ziaunys, Mantas; Sakalauskas, Andrius; Sneideris, Tomas; Smirnovas, Vytautas; Chaudhary, Himanshu; Morozova-Roche, Ludmilla A.; Ono, Kenjiro
- Abstract
Protein aggregation into amyloid fibrils is linked to multiple disorders. The understanding of how natively non-harmful proteins convert to these highly cytotoxic amyloid aggregates is still not sufficient, with new ideas and hypotheses being presented each year. Recently it has been shown that more than one type of protein aggregates may co-exist in the affected tissue of patients suffering from amyloid-related disorders, sparking the idea that amyloid aggregates formed by one protein may induce another protein's fibrillization. In this work, we examine the effect that lysozyme fibrils have on insulin amyloid aggregation. We show that not only do lysozyme fibrils affect insulin nucleation, but they also alter the mechanism of its aggregation.
- Subjects
LYSOZYMES; INSULIN; AMYLOID beta-protein; AMYLOID; PROTEINS
- Publication
International Journal of Molecular Sciences, 2021, Vol 22, Issue 4, p1775
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms22041775