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- Title
Sex-Specific Patterns of Aberrant Brain Function in First-Episode Treatment-Naive Patients with Schizophrenia.
- Authors
Wei Lei; Mingli Li; Wei Deng; Yi Zhou; Xiaohong Ma; Qiang Wang; Wanjun Guo; Yinfei Li; Lijun Jiang; Yuanyuan Han; Chaohua Huang; Xun Hu; Tao Li
- Abstract
Male and female patients with schizophrenia show significant differences in a number of important clinical features, yet the neural substrates of these differences are still poorly understood. Here we explored the sex differences in the brain functional aberrations in 124 treatment-naïve patients with first-episode schizophrenia (61 males), compared with 102 age-matched healthy controls (50 males). Maps of degree centrality (DC) and amplitude of low-frequency fluctuations (ALFF) were constructed using resting-state functional magnetic resonance imaging data and compared between groups. We found that: (1) Selective DC reduction was observed in the right putamen (Put_R) in male patients and the left middle frontal gyrus (MFG) in female patients; (2) Functional connectivity analysis (using Put_R and MFG as seeds) found that male and female patients have disturbed functional integration in two separate networks, i.e., the sensorimotor network and the default mode network; (3) Significant ALFF alterations were also observed in these two networks in both genders; (4) Sex specific brain functional alterations were associated with various symptoms in patients. These results suggested that sex-specific patterns of functional aberration existed in schizophrenia, and these patterns were associated with the clinical features both in male and female patients.
- Subjects
SCHIZOPHRENIA treatment; BRAIN physiology; GENDER differences (Psychology); MAGNETIC resonance imaging of the brain; BIOLOGICAL neural networks
- Publication
International Journal of Molecular Sciences, 2015, Vol 16, Issue 7, p16125
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms160716125