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- Title
Astaxanthin alleviates PM<sub>2.5</sub>-induced cardiomyocyte injury via inhibiting ferroptosis.
- Authors
Ren, Jingyi; Yin, Bowen; Guo, Zihao; Sun, Xiaoya; Pei, Huanting; Wen, Rui; Wang, Ziyi; Zhu, Siqi; Zuo, Jinshi; Zhang, Yadong; Ma, Yuxia
- Abstract
Background: Long-term exposure of humans to air pollution is associated with an increasing risk of cardiovascular diseases (CVDs). Astaxanthin (AST), a naturally occurring red carotenoid pigment, was proved to have multiple health benefits. However, whether or not AST also exerts a protective effect on fine particulate matter (PM2.5)-induced cardiomyocyte damage and its underlying mechanisms remain unclear. Methods: In vitro experiments, the H9C2 cells were subjected to pretreatment with varying concentrations of AST, and then cardiomyocyte injury model induced by PM2.5 was established. The cell viability and the ferroptosis-related proteins expression were measured in different groups. In vivo experiments, the rats were pretreated with different concentrations of AST for 21 days. Subsequently, a rat model of myocardial PM2.5 injury was established by intratracheal instillation every other day for 1 week. The effects of AST on myocardial tissue injury caused by PM2.5 indicating by histological, serum, and protein analyses were examined. Results: AST significantly ameliorated PM2.5-induced myocardial tissue injury, inflammatory cell infiltration, the release of inflammatory factors, and cardiomyocyte H9C2 cell damage. Mechanistically, AST pretreatment increased the expression of SLC7A11, GPX4 and down-regulated the expression of TfR1, FTL and FTH1 in vitro and in vivo. Conclusions: Our study suggest that ferroptosis plays a significant role in the pathogenesis of cardiomyocyte injury induced by PM2.5. AST may serve as a potential therapeutic agent for mitigating cardiomyocyte injury caused by PM2.5 through the inhibition of ferroptosis.
- Publication
Cellular & Molecular Biology Letters, 2023, Vol 28, Issue 1, p1
- ISSN
1425-8153
- Publication type
Article
- DOI
10.1186/s11658-023-00513-1