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- Title
An HLA-A*02:01-B*13:01-DRB1*14:01:03 haplotype conserved in Taiwanese and a possible close relationship between DRB1*14:01:03 and DRB1*14:54.
- Authors
Yang, K. L.; Lee, S. K.; Chu, C. C.; Lin, C. C.; Jiang, S.; Chiu, H. M.; Lin, S.; Chen, Y. C.; Chen, M. J.; Jian, Y. F.; Yang, C. F.; Yang, S. Y.; Shyr, M. J.; Lin, C. L.; Lin, P. Y.
- Abstract
We here report sequence confirmation and analysis of the variant HLA-DRB1*14:01:03 on three voluntary bone marrow donors and the conserved haplotype carrying DRB1*14:01:03 allele in Taiwanese population. In exon 2, the DNA sequence of DRB1*14:01:03 is identical to HLA-DRB1*14:01:01 except a silent nucleotide substitution at position 192. However, sequence specific primer (SSP) reaction pattern of DRB1*14:01:03 matched with the pattern of DRB1*14:54 instead of DRB1*14:01:01, 14:01:02 or 14:01:03. In exon 3, at position 421, DRB1*14:01:03 has an identical nucleotide as DRB1*14:54 but differs from DRB1*14:01:01. We think the discrepancy of the allele assignment by SSP typing protocol and by sequence-specific oligonucleotide probe (SSO) and sequence-based typing methods should be addressed. We assume DRB1*14:54 is probably the parental allele for DRB1*14:01:03.
- Subjects
ORGAN donors; BONE marrow; NUCLEOTIDE sequence; NUCLEIC acid probes; GENE frequency
- Publication
International Journal of Immunogenetics, 2011, Vol 38, Issue 1, p69
- ISSN
1744-3121
- Publication type
Article
- DOI
10.1111/j.1744-313X.2010.00970.x