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- Title
New Trimethoxybenzamides and Trimethoxyphenylureas Derived from Dimethylcarbazole as Cytotoxic Agents. Part I.
- Authors
Panno, Antonella; Sinicropi, Maria Stefania; Caruso, Anna; El ‐ Kashef, Hussein; Lancelot, Jean ‐ Charles; Aubert, Geneviève; Lesnard, Aurélien; Cresteil, Thierry; Rault, Sylvain
- Abstract
A convenient synthesis of novel functionalized 1,4-dimethylcarbazole derivatives containing 3,4,5-trimethoxybenzamido-ureido or N-(3,4,5-trimethoxyphenyl)ureido group starting from their corresponding indole derivatives is reported. Three derivatives prepared ( 5g, 6c, and 6g) were active against leukemia cell lines HL60. Both 5g and 6g showed potent antiproliferative activity against KB cell lines, likely associated with the inhibition of tubulin .
- Subjects
BENZAMIDE; PHENYLUREA compounds; CARBAZOLE; INDOLE derivatives; TUBULINS
- Publication
Journal of Heterocyclic Chemistry, 2014, Vol 51, pE294
- ISSN
0022-152X
- Publication type
Article
- DOI
10.1002/jhet.1951