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- Title
Meniscal allograft transplantation after meniscectomy: clinical effectiveness and cost-effectiveness.
- Authors
Waugh, Norman; Mistry, Hema; Royle, Pamela; Metcalfe, Andrew; Loveman, Emma; Colquitt, Jill; Smith, Nick A.; Spalding, Tim
- Abstract
<bold>Purpose: </bold>To assess the clinical effectiveness and cost-effectiveness of meniscal allograft transplantation (MAT) after meniscal injury and subsequent meniscectomy.<bold>Methods: </bold>Systematic review of clinical effectiveness and cost-effectiveness analysis.<bold>Results: </bold>There is considerable evidence from observational studies, of improvement in symptoms after meniscal allograft transplantation, but we found only one small pilot trial with a randomised comparison with a control group that received non-surgical care. MAT has not yet been proven to be chondroprotective. Cost-effectiveness analysis is not possible due to a lack of data on the effectiveness of MAT compared to non-surgical care.<bold>Conclusion: </bold>The benefits of MAT include symptomatic relief and restoration of at least some previous activities, which will be reflected in utility values and hence in quality-adjusted life years, and in the longer term, prevention or delay of osteoarthritis, and avoidance or postponement of some knee replacements, with resulting savings. It is likely to be cost-effective, but this cannot be proven on the basis of present evidence.<bold>Level Of Evidence: </bold>IV.
- Subjects
MENISCECTOMY; HOMOGRAFTS; COST effectiveness; HEALTH outcome assessment; DRUG efficacy; OSTEOARTHRITIS
- Publication
Knee Surgery, Sports Traumatology, Arthroscopy, 2019, Vol 27, Issue 6, p1825
- ISSN
0942-2056
- Publication type
journal article
- DOI
10.1007/s00167-019-05504-4