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- Title
Severe intestinal toxicity after stereotactic ablative radiotherapy for abdominopelvic malignancies.
- Authors
Bae, Sun Hyun; Kim, Mi-Sook; Kim, So Young; Jang, Won Il; Cho, Chul Koo; Yoo, Hyung Jun; Kim, Kum Bae; Lee, Dong Han; Han, Chul Ju; Yang, Ki Young; Kim, Sang Bum
- Abstract
Purpose: The purpose of this study is to identify the predictors for severe intestinal toxicity (IT) in patients with abdominopelvic malignancies treated with three fractions of stereotactic ablative radiotherapy (SABR). Methods: From 2001 to 2011, 202 patients with abdominopelvic malignancies were treated with curative-intent SABR. Among these, we retrospectively reviewed the clinical records of 55 patients with the presence of the intestine that received a dose ≥20 % of the prescribed dose. The total dose ranged from 33 to 60 Gy in three fractionations (median dose, 45 Gy). We analyzed the clinical and dosimetric parameters for severe IT ≥ grade 3 according to the National Cancer Institute Common Toxicity Criteria v4.0: V20–35 (volume of the intestine that received xGy) and Dmax (maximum point dose). Results: Severe IT was found in six patients (the median time, 3 months). V25 was the best dosimetric predictor for severe IT ( P = 0.004). With V25 ≤ 20 ml, severe IT decreased from 50 to 4 %. SABR duration was the best clinical predictor. Severe IT decreased in patients who received SABR at 4–8 days than on three consecutive days (0 vs. 18 %, P = 0.037). Conclusions: Following three fractions of SABR, V25 is a valuable predictor of severe IT. And SABR would be conducted with a treatment interval of at least 48 h if possible.
- Subjects
INTESTINAL disease treatment; RADIOTHERAPY; DOSE fractionation; FOOD toxicology; MEDICAL records
- Publication
International Journal of Colorectal Disease, 2013, Vol 28, Issue 12, p1707
- ISSN
0179-1958
- Publication type
Article
- DOI
10.1007/s00384-013-1717-6