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- Title
Detection and characterization of neurotoxicity in cancer patients using proton MR spectroscopy.
- Authors
Emilie Steffen-Smith; Paul Albert; Eva Baker; Kim Shimoda; Alan Barnett
- Abstract
Abstract Objective The study objective was to detect abnormalities and identify relationships between brain metabolic ratios determined by proton magnetic resonance spectroscopic imaging (1H-MRSI) and neuropsychological (NP) function in cancer patients at risk for neurotoxicity. Methods Thirty-two patients received 1H-MRSI using a multi-slice, multi-voxel technique on a 1.5T magnet. Cho/NAA, NAA/Cr, and Cho/Cr ratios were identified in seven pre-determined sites without tumor involvement. A battery of age-appropriate NP tests was administered within 7 days of imaging. Relationships were examined between test scores and metabolite ratios. Conclusions This study identifies relationships between brain metabolite ratios and cognitive functioning in cancer patients. 1H-MRSI may be useful in early detection of neurotoxic effects, but prospective longitudinal studies in a homogeneous population are recommended to determine the prognostic value.
- Subjects
HUMAN abnormalities; PROTON magnetic resonance; NEUROPSYCHOLOGICAL tests; NEUROTOXICOLOGY
- Publication
Child's Nervous System, 2008, Vol 24, Issue 7, p807
- ISSN
0256-7040
- Publication type
Article
- DOI
10.1007/s00381-007-0576-2