We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Strategies adopted by Salmonella to survive in host: a review.
- Authors
Li, Wanwu; Ren, Qili; Ni, Ting; Zhao, Yifei; Sang, Zichun; Luo, Renli; Li, Zhongjie; Li, Sanqiang
- Abstract
Salmonella, a Gram-negative bacterium that infects humans and animals, causes diseases ranging from gastroenteritis to severe systemic infections. Here, we discuss various strategies used by Salmonella against host cell defenses. Epithelial cell invasion largely depends on a Salmonella pathogenicity island (SPI)-1-encoded type 3 secretion system, a molecular syringe for injecting effector proteins directly into host cells. The internalization of Salmonella into macrophages is primarily driven by phagocytosis. After entering the host cell cytoplasm, Salmonella releases many effectors to achieve intracellular survival and replication using several secretion systems, primarily an SPI-2-encoded type 3 secretion system. Salmonella-containing vacuoles protect Salmonella from contacting bactericidal substances in epithelial cells and macrophages. Salmonella modulates the immunity, metabolism, cell cycle, and viability of host cells to expand its survival in the host, and the intracellular environment of Salmonella-infected cells promotes its virulence. This review provides insights into how Salmonella subverts host cell defenses for survival.
- Publication
Archives of Microbiology, 2023, Vol 205, Issue 12, p1
- ISSN
0302-8933
- Publication type
Article
- DOI
10.1007/s00203-023-03702-w