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- Title
More than a co-incidence? Comment on: Amyotrophic lateral sclerosis is over‐represented in two Huntington's disease brain bank cohorts: further evidence to support genetic pleiotropy of pathogenic HTT gene expansion.
- Authors
Bakels, Hannah S.; Feleus, Stephanie; van Dis, Vera; de Bot, Susanne T.
- Abstract
With interest we took notice of the recent paper by Hickman and colleagues on the over-representation of Amyotrophic Lateral Sclerosis (ALS) pathology in Huntington Disease (HD) brains [[4]]. One could argue that reassessment of the I initial i neuropathology reports, of both HD and ET brains, gives a higher a priori likelihood of finding ALS neuropathology in HD brains than in ET brains, based on their clinical overlap and common neurodegenerative pathomechanisms. Comment on: Amyotrophic lateral sclerosis is over-represented in two Huntington's disease brain bank cohorts: further evidence to support genetic pleiotropy of pathogenic HTT gene expansion.
- Subjects
AMYOTROPHIC lateral sclerosis; HUNTINGTON disease; GENETIC pleiotropy; BRAIN banks; BRAIN diseases; MOTOR neuron diseases; MOTOR neurons
- Publication
Acta Neuropathologica, 2023, Vol 145, Issue 2, p257
- ISSN
0001-6322
- Publication type
Article
- DOI
10.1007/s00401-022-02517-1