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- Title
Exposure to Therapeutic Concentrations of Ritonavir, but Not Saquinavir, Reduces Secreted Aspartyl Proteinase of Candida parapsilosis.
- Authors
Asencio, M. A.; Garduño, E.; Pérez-Giraldo, C.; Blanco, M. T.; Hurtado, C.; Gómez-García, A. C.
- Abstract
The effect of ritonavir and saquinavir, HIV proteinase inhibitors, on the secreted aspartyl proteinase (Sap) activity of Candida parapsilosis was studied. In a proteinase-inducing medium (yeast carbon base-bovine serum albumin), Sap activity in all clinical isolates of C. parapsilosis (n = 20) was observed at 37°C but not at 22°C. The presence of ritonavir at a concentration of 8 μg/ml produced an inhibition close to 50% albumin consumption and also delayed yeast growth; however, saquinavir did not have any effect on growth or on Sap activity. In Sabouraud broth, which does not induce Sap production, no effect was shown on yeast growth by either of the two HIV proteinase inhibitors studied. Copyright © 2005 S. Karger AG, Basel
- Subjects
PROTEINASES; ENZYME inhibitors; ALBUMINS; PROTEOLYTIC enzymes; CHEMICAL inhibitors
- Publication
Chemotherapy (0009-3157), 2005, Vol 51, Issue 5, p252
- ISSN
0009-3157
- Publication type
Article
- DOI
10.1159/000087252