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- Title
Developmental biology: Jumping-gene roulette.
- Authors
Martin, Sandra L.
- Abstract
The article focuses on the capability of jumping genes to provide a stochastic process for generating brain diversity among humans. It relates that the complexity of the human nervous system is generated by the combined actions between genetic and environmental factors. It stresses the aspect of DNA methylation in regulatory regions of genes as an effective method of transcriptional repression. It indicates that human neural progenitor cells support the retrotransposition of an introduced human LINE-1 (L1) retrotransposons, the regions of mobile DNA that make copies of themselves by converting their RNA transcript into DNA.
- Subjects
DEVELOPMENTAL genetics; STOCHASTIC processes; DNA synthesis; TRANSCRIPTION factors; GENETIC regulation; MOBILE genetic elements; NUCLEOTIDE sequence; NERVOUS system; RNA
- Publication
Nature, 2009, Vol 460, Issue 7259, p1087
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/4601087a