We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Informing Prevention and Intervention Policy Using Genetic Studies of Resistance.
- Authors
Maher, Brion S.; Latendresse, Shawn; Vanyukov, Michael M.
- Abstract
The common paradigm for conceptualizing the influence of genetic and environmental factors on a particular disease relies on the concept of risk. Consequently, the bulk of etiologic, including genetic, work focuses on "risk" factors. These factors are aggregated at the high end of the distribution of liability to disease, the latent variable underlying the distribution of probability and severity of a disorder. However, liability has a symmetric but distinct aspect to risk, resistance to disorder. Resistance factors, aggregated at the low end of the liability distribution and supporting health and recovery, appear to be more promising for effective prevention and intervention. Herein, we discuss existing work on resistance factors, highlighting those with known genetic influences. We examine the utility of incorporating resistance genetics in prevention and intervention trials and compare the statistical power of a series of ascertainment schemes to develop a general framework for examining resistance outcomes in genetically informative designs. We find that an approach that samples individuals discordant on measured liability, a low-risk design, is the most feasible design and yields power equivalent to or higher than commonly used designs for detecting resistance genetic and environmental effects.
- Subjects
GENES; EPIDEMIOLOGY; ETIOLOGY of diseases; HEREDITY; DISEASES
- Publication
Prevention Science, 2018, Vol 19, Issue 1, p49
- ISSN
1389-4986
- Publication type
journal article
- DOI
10.1007/s11121-016-0730-8