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- Title
Ancestral susceptibility to colorectal cancer.
- Authors
Huhn, Stefanie; Pardini, Barbara; Naccarati, Alessio; Vodička, Pavel; Hemminki, Kari; Försti, Asta
- Abstract
Every year, approximately 1 million new colorectal cancer (CRC) cases are diagnosed and about half a million people worldwide die due to this cancer. Known differences in CRC incidence rates are mainly attributed to differences in diet and other environmental factors represented, among others, by nutrition-related complex diseases (e.g. obesity and diabetes mellitus type II). Within the last years, it has become evident that environmental risk factors can be complemented by a genetic component when considering the risk of CRC. For example, a number of polymorphisms are known to be associated with an increased risk of obesity and obesity is a risk factor for CRC. Several studies have shown that the ‘ancestral-susceptibility model’ can be reasonably applied to nutrition-related complex diseases such as obesity. The work in hand shortly discusses whether the ancestral-susceptibility model can also be applied to CRC as a nutrition-related complex disease.
- Subjects
COLON cancer risk factors; CANCER susceptibility; CANCER genetics; NUTRITIONALLY induced diseases; GENETIC polymorphisms; GENETIC disorders; OBESITY risk factors
- Publication
Mutagenesis, 2012, Vol 27, Issue 2, p197
- ISSN
0267-8357
- Publication type
Article
- DOI
10.1093/mutage/ger061