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- Title
Goal-directed and habitual control in the basal ganglia: implications for Parkinson's disease.
- Authors
Redgrave, Peter; Rodriguez, Manuel; Smith, Yoland; Rodriguez-Oroz, Maria C.; Lehericy, Stephane; Bergman, Hagai; Agid, Yves; DeLong, Mahlon R.; Obeso, Jose A.
- Abstract
Progressive loss of the ascending dopaminergic projection in the basal ganglia is a fundamental pathological feature of Parkinson's disease. Studies in animals and humans have identified spatially segregated functional territories in the basal ganglia for the control of goal-directed and habitual actions. In patients with Parkinson's disease the loss of dopamine is predominantly in the posterior putamen, a region of the basal ganglia associated with the control of habitual behaviour. These patients may therefore be forced into a progressive reliance on the goal-directed mode of action control that is mediated by comparatively preserved processing in the rostromedial striatum. Thus, many of their behavioural difficulties may reflect a loss of normal automatic control owing to distorting output signals from habitual control circuits, which impede the expression of goal-directed action.
- Subjects
BASAL ganglia; PARKINSON'S disease; DOPAMINE; HUMAN behavior; PROCESS control systems; ANIMAL experimentation; BIOLOGICAL models; COMPARATIVE studies; GOAL (Psychology); LEARNING; RESEARCH methodology; MEDICAL cooperation; NERVOUS system; RESEARCH; RESEARCH funding; EVALUATION research; NEURAL pathways; PHYSIOLOGY
- Publication
Nature Reviews Neuroscience, 2010, Vol 11, Issue 11, p760
- ISSN
1471-003X
- Publication type
research
- DOI
10.1038/nrn2915