We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
High prevalence and indexes of anti-John Cunningham virus antibodies in a cohort of Chinese patients with multiple sclerosis.
- Authors
Lau, Alexander; Wei Qiu; Kermode, Allan; Au, Cheryl; Ng, Angel; Wong, Adrian; Sze-Ho Ma; Au, Lisa; Ma, Karen; Ip, Bonaventure; Mok, Vincent
- Abstract
We performed a cross-sectional study in 123 Chinese multiple sclerosis patients residing in Hong Kong to evaluate their anti-John Cunningham virus status using STRATIFY JCV DxSelect assays. Anti-John Cunningham virus antibody was present in 98/123 (80%) subjects, among which 75/98 (77%) had an anti-John Cunningham virus index ≥1.5. Anti-John Cunningham virus antibody seropositivity was not correlated with age, disease duration, Expanded Disability Status Scale scores, types of multiple sclerosis (relapsing vs progressive), or disease-modifying treatments used. We found a very high seroprevalence and index of anti-John Cunningham virus antibodies in Chinese multiple sclerosis patients, which may impact the risk assessment and recommendation of disease-modifying treatments in this population.
- Subjects
MULTIPLE sclerosis; RISK assessment; CROSS-sectional method; IMMUNOGLOBULINS; PROGRESSIVE multifocal leukoencephalopathy; PATIENTS
- Publication
Multiple Sclerosis Journal - Experimental, Translational & Clinical, 2018, Vol 4, Issue 3, p1
- ISSN
2055-2173
- Publication type
Article
- DOI
10.1177/2055217318788699