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- Title
P-708 - Genetic risk factors for interferon-alpha induced depression
- Authors
Martín-Santos, R.; Navinés, R.; Udina, M.; Giménez, D.; Moreno, J.; Castellví, P.; Langhor, K.; Gutiérrez, F.; Gómez, E.; Gratacòs, M.; Valdés, M.; Solà, R.
- Abstract
Background/aims: Chronic hepatitis C infection (CHC) represents a public health problem that affects around 3% of population worldwide. Pegylated Interferon-alpha (PegIFN-α) and Ribavirin (RBV) is the recommended treatment reaching about 40–80% of sustained virological response. However, a common treatment side-effect is induced-depression that impairs patient''s quality of life and treatment adherence (1,2). This paper showed polymorphisms in HTR1A, NCR1, TPH2 genes as predictive variables of IFN-induced depression. Material/methods: 396 consecutive, euthymic, CHC outpatients treated with PegIFN-α/RBV were included. Patients were assessed at baseline, 4, 12, 24 and 48 weeks of treatment using PHQ and MINI-DSM-IV-R interview to diagnose depression. Survival analysis was performed. In the univariated analysis functions were compared using logrank test. Significative variables (0.1 level) were extracted for the multivariated model, using a Weibull regression model. Results: The incidence of induced-depression along the treatment was 39.4%. Polimorphisms on HTR1A (P=0.0104), TPH2 (P=0.0231) and NRC1 (P=0.0702) genes predicted IFN-induced depression. Conclusions: Genes related with serotonine and inflamation system may play an important role in the pathogenesis of IFN-induced depression. Knowledge of predictive variables for IFN-induced depression may help to better manage patients at risk.
- Subjects
INTERFERONS; MENTAL depression; HEPATITIS C; PUBLIC health; GENETIC polymorphisms; OUTPATIENT medical care
- Publication
European Psychiatry, 2012, Vol 27, p1
- ISSN
0924-9338
- Publication type
Abstract
- DOI
10.1016/S0924-9338(12)74875-7