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- Title
Oral glucose tolerance tests in treated patients with schizophrenia.: Data to support an adaptation of the proposed guidelines for monitoring of patients on second generation antipsychotics?
- Authors
De Hert, Marc; Van Eyck, Dominique; Hanssens, Linda; Peuskens, Hendrik; Thys, Erik; Wampers, Martien; Scheen, Andre; Peuskens, Jozef
- Abstract
Abstract: Objective. – A recent consensus conference has proposed guidelines for the monitoring for diabetes in patients with schizophrenia and also identifies the need of long-term prospective studies. Method. – A large scale prospective study on metabolic risks of antipsychotic medication is currently ongoing. At baseline, patients get a full laboratory screening, ECG and an oral glucose tolerance test (OGTT). Baseline data on 100 non-diabetic patients at study inclusion and stable on medication for at least 6 months are presented. Results. – Glucose abnormalities are found in 22% of patients at baseline. A monitoring protocol based only on fasting glucose would not have detected 63.6% of these patients with classifiable glucose abnormalities in our sample. Fasting insulin and measures for insulin resistance have a high predictive value for abnormalities late in the OGTT. Conclusion. – Already at baseline, metabolic problems are frequently present in patients with schizophrenia treated with antipsychotics. Adding assessment of fasting insulin in a monitoring protocol improves detection of glucose abnormalities late in an OGTT.
- Subjects
GLUCOSE tolerance tests; DIABETES; PEOPLE with schizophrenia; ANTIPSYCHOTIC agents
- Publication
European Psychiatry, 2006, Vol 21, Issue 4, p224
- ISSN
0924-9338
- Publication type
Article
- DOI
10.1016/j.eurpsy.2005.05.011