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- Title
Lead-Induced Hepato-Renal Toxicosis and the Ameliorative Role of Rhodiolarosea Extract in Albino Rats .
- Authors
Mahamat, Ibrahim A.; Mehanna, El Sayed E.; Oda, Samah S.; Khafaga, Asmaa F.; Gad El-Karim, Dina R. S.
- Abstract
Lead is one of the toxic heavy metals which were proved to induce several deleterious changesin different body organs especially central nervous system, liver and kidney.Rhoidiola species are medicinal plants which were used in treatment of several diseases for many years all over the world. This study was designed to detect the hematological, biochemical and pathological changes in relation to lead-induced hepat- renal toxicity, besides the possible ameliorative role of Rhodiolarosea extract against this toxicity in rats. Oral exposure of rats to lead acetate (25mg/Kg) for eight weeks resulted in a significant increase in liver-related enzymes (AST, ALT and ALP), different types of bilirubin, disturbance in serum proteinogram, besides a significant elevation in serum urea and creatinine level, without any significant changes in hemograme. Lead-induced oxidative stress in both of hepatic and renal tissues was indicated by depletion of their glutathione (GSH) content, decreased catalase enzyme (CAT) activity and elevated content of malondialdehyde (MDA). The previous changes were confirmed histopathologically by presence of several necrotic and degenerative lesions in hepatic and renal tissues. Contrariwise, the above-mentioned changes were partially ameliorated upon co- administration of Rhodiolarosea extract (200 and 400 mg/Kg), but high dose of Rhodiola extract mostly mitigated these changes than 200 mg/Kg dose. In conclusion, Rhodiola extract can ameliorate lead-induced hepato-nephrotoxicity and its related biochemical and pathological changes.
- Subjects
ALANINE aminotransferase; PATHOLOGICAL physiology; POISONING; ORGANS (Anatomy); CENTRAL nervous system; NEPHROTOXICOLOGY
- Publication
Alexandria Journal of Veterinary Sciences, 2021, Vol 70, Issue 2, p76
- ISSN
1110-2047
- Publication type
Article
- DOI
10.5455/ajvs.90234