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- Title
A Novel Targeted Learning Method for Quantitative Trait Loci Mapping.
- Authors
Hui Wang; Zhongyang Zhang; Rose, Sherri; van der Laan, Mark
- Abstract
We present a novel semiparametric method for quantitative trait loci (QTL) mapping in experimental crosses. Conventional genetic mapping methods typically assume parametric models with Gaussian errors and obtain parameter estimates through maximum-likelihood estimation. In contrast with univariate regression and interval-mapping methods, our model requires fewer assumptions and also accommodates various machine-learning algorithms. Estimation is performed with targeted maximum-likelihood learning methods. We demonstrate our semiparametric targeted learning approach in a simulation study and a well-studied barley data set.
- Subjects
GENE mapping research; GAUSSIAN processes; LOCUS (Genetics); ESTIMATION theory; ALGORITHM research
- Publication
Genetics, 2014, Vol 198, Issue 4, p1369
- ISSN
0016-6731
- Publication type
Article
- DOI
10.1534/genetics.114.168955