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Site-specific genome editing in Plasmodium falciparum using engineered zinc-finger nucleases.
Published in:
Nature Methods, 2012, v. 9, n. 10, p. 993, doi. 10.1038/nmeth.2143
By:
- Straimer, Judith;
- Lee, Marcus C S;
- Lee, Andrew H;
- Zeitler, Bryan;
- Williams, April E;
- Pearl, Jocelynn R;
- Zhang, Lei;
- Rebar, Edward J;
- Gregory, Philip D;
- Llinás, Manuel;
- Urnov, Fyodor D;
- Fidock, David A
Publication type:
Article
Editing the Plasmodium vivax genome, using zinc-finger nucleases.
Published in:
2015
By:
- Moraes Barros, Roberto R;
- Straimer, Judith;
- Sa, Juliana M;
- Salzman, Rebecca E;
- Melendez-Muniz, Viviana A;
- Mu, Jianbing;
- Fidock, David A;
- Wellems, Thomas E
Publication type:
journal article
In Vivo and In Vitro Efficacy of Amodiaquine against Plasmodium falciparum in an Area of Continued Use of 4-Aminoquinolines in East Africa.
Published in:
Journal of Infectious Diseases, 2009, v. 199, n. 11, p. 1575, doi. 10.1086/598862
By:
- Sasi, Philip;
- Abdulrahaman, Abdi;
- Mwai, Leah;
- Muriithi, Steven;
- Straimer, Judith;
- Schieck, Elise;
- Rippert, Anja;
- Bashraheil, Mahfudh;
- Salim, Amina;
- Peshu, Judith;
- Awuondo, Ken;
- Lowe, Brett;
- Pirmohamed, Munir;
- Winstanley, Peter;
- Ward, Steve;
- Nzila, Alexis;
- Borrmann, Steffen
Publication type:
Article
Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness.
Published in:
eLife, 2021, p. 1, doi. 10.7554/eLife.66277
By:
- Stokes, Barbara H.;
- Dhingra, Satish K.;
- Rubiano, Kelly;
- Mok, Sachel;
- Straimer, Judith;
- Gnädig, Nina F.;
- Deni, Ioanna;
- Schindler, Kyra A.;
- Bath, Jade R.;
- Ward, Kurt E.;
- Striepen, Josefine;
- Yeo, Tomas;
- Ross, Leila S.;
- Legrand, Eric;
- Ariey, Frédéric;
- Cunningham, Clark H.;
- Souleymane, Issa M.;
- Gansané, Adama;
- Nzoumbou-Boko, Romaric;
- Ndayikunda, Claudette
Publication type:
Article
Balancing drug resistance and growth rates via compensatory mutations in the P lasmodium falciparum chloroquine resistance transporter.
Published in:
Molecular Microbiology, 2015, v. 97, n. 2, p. 381, doi. 10.1111/mmi.13035
By:
- Petersen, Ines;
- Gabryszewski, Stanislaw J.;
- Johnston, Geoffrey L.;
- Dhingra, Satish K.;
- Ecker, Andrea;
- Lewis, Rebecca E.;
- Almeida, Mariana Justino;
- Straimer, Judith;
- Henrich, Philipp P.;
- Palatulan, Eugene;
- Johnson, David J.;
- Coburn‐Flynn, Olivia;
- Sanchez, Cecilia;
- Lehane, Adele M.;
- Lanzer, Michael;
- Fidock, David A.
Publication type:
Article
Generation of Transmission-Competent Human Malaria Parasites with Chromosomally-Integrated Fluorescent Reporters.
Published in:
Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-49348-x
By:
- McLean, Kyle Jarrod;
- Straimer, Judith;
- Hopp, Christine S.;
- Vega-Rodriguez, Joel;
- Small-Saunders, Jennifer L.;
- Kanatani, Sachie;
- Tripathi, Abhai;
- Mlambo, Godfree;
- Dumoulin, Peter C.;
- Harris, Chantal T.;
- Tong, Xinran;
- Shears, Melanie J.;
- Ankarklev, Johan;
- Kafsack, Björn F. C.;
- Fidock, David A.;
- Sinnis, Photini
Publication type:
Article
A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance.
Published in:
Nature Communications, 2017, v. 8, n. 5, p. 15159, doi. 10.1038/ncomms15159
By:
- O'Neill, Paul M.;
- Amewu, Richard K.;
- Charman, Susan A.;
- Sabbani, Sunil;
- Gnädig, Nina F.;
- Straimer, Judith;
- Fidock, David A.;
- Shore, Emma R.;
- Roberts, Natalie L.;
- Wong, Michael H.-L.;
- Hong, W. David;
- Pidathala, Chandrakala;
- Riley, Chris;
- Murphy, Ben;
- Aljayyoussi, Ghaith;
- Gamo, Francisco Javier;
- Sanz, Laura;
- Rodrigues, Janneth;
- Cortes, Carolina Gonzalez;
- Herreros, Esperanza
Publication type:
Article
Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies.
Published in:
Nature Communications, 2016, v. 7, n. 5, p. 11553, doi. 10.1038/ncomms11553
By:
- Veiga, M. Isabel;
- Dhingra, Satish K.;
- Henrich, Philipp P.;
- Straimer, Judith;
- Gnädig, Nina;
- Uhlemann, Anne-Catrin;
- Martin, Rowena E.;
- Lehane, Adele M.;
- Fidock, David A.
Publication type:
Article
Efficacy of Cipargamin (KAE609) in a Randomized, Phase II Dose-Escalation Study in Adults in Sub-Saharan Africa With Uncomplicated Plasmodium falciparum Malaria.
Published in:
Clinical Infectious Diseases, 2022, v. 74, n. 10, p. 1831, doi. 10.1093/cid/ciab716
By:
- Schmitt, Esther K;
- Ndayisaba, Gilles;
- Yeka, Adoke;
- Asante, Kwaku Poku;
- Grobusch, Martin P;
- Karita, Etienne;
- Mugerwa, Henry;
- Asiimwe, Stephen;
- Oduro, Abraham;
- Fofana, Bakary;
- Doumbia, Seydou;
- Su, Guoqin;
- Renner, Katalin Csermak;
- Venishetty, Vinay Kumar;
- Sayyed, Sarfaraz;
- Straimer, Judith;
- Demin, Ivan;
- Barsainya, Sarita;
- Boulton, Caroline;
- Gandhi, Preetam
Publication type:
Article
Targeting the Cell Stress Response of Plasmodium falciparum to Overcome Artemisinin Resistance.
Published in:
PLoS Biology, 2015, v. 13, n. 4, p. 1, doi. 10.1371/journal.pbio.1002132
By:
- Dogovski, Con;
- Xie, Stanley C.;
- Burgio, Gaetan;
- Bridgford, Jess;
- Mok, Sachel;
- McCaw, James M.;
- Chotivanich, Kesinee;
- Kenny, Shannon;
- Gnädig, Nina;
- Straimer, Judith;
- Bozdech, Zbynek;
- Fidock, David A.;
- Simpson, Julie A.;
- Dondorp, Arjen M.;
- Foote, Simon;
- Klonis, Nectarios;
- Tilley, Leann
Publication type:
Article
High Prevalence of Plasmodium falciparum K13 Mutations in Rwanda Is Associated With Slow Parasite Clearance After Treatment With Artemether-Lumefantrine.
Published in:
2022
By:
- Straimer, Judith;
- Gandhi, Preetam;
- Renner, Katalin Csermak;
- Schmitt, Esther K
Publication type:
journal article
Insights into the intracellular localization, protein associations and artemisinin resistance properties of Plasmodium falciparum K13.
Published in:
PLoS Pathogens, 2020, v. 16, n. 4, p. 1, doi. 10.1371/journal.ppat.1008482
By:
- Gnädig, Nina F.;
- Stokes, Barbara H.;
- Edwards, Rachel L.;
- Kalantarov, Gavreel F.;
- Heimsch, Kim C.;
- Kuderjavy, Michal;
- Crane, Audrey;
- Lee, Marcus C. S.;
- Straimer, Judith;
- Becker, Katja;
- Trakht, Ilya N.;
- Odom John, Audrey R.;
- Mok, Sachel;
- Fidock, David A.
Publication type:
Article

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