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- Title
HBV 父婴垂直传播的研究进展.
- Authors
张凯; 蔺淑梅; 杨雪亮; 孔颖; 刘小静; 张曦; 石磊; 陈云茹; 叶峰; 李娜
- Abstract
Hepatitis B virus (HBV) infection is a global public health problem which greatly threatens human health. Paternal-fetal vertical transmission (P-FT) is one of the leading causes of persistent HBV infection, and has a transmission rate similar to that of mother-to-child vertical transmission. In recent years, P-FT has been attracting more and more attention and has become a hot research topic at home and abroad. It has been confirmed that P-FT occurs via sperm, but the mechanism remains unknown. Studies have shown that a high HBV DNA load in serum and semen and positive serum HBeAg are the major risk factors for the occurrence of P-FT. Random integration of HBV DNA into sperm can affect sperm quality, cause male infertility, and even affect the maternal pregnancy outcome. Currently the most important measure to block P-FT is pre-pregnancy intervention, including antiviral therapy for the father and active immunization for the mother.
- Publication
Journal of Clinical Hepatology / Linchuang Gandanbing Zazhi, 2016, Vol 32, Issue 3, p579
- ISSN
1001-5256
- Publication type
Article
- DOI
10.3969/j.issn.1001-5256.2016.03.040