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- Title
Leflunomide for the treatment of trichodysplasia spinulosa in a liver transplant recipient.
- Authors
Kassar, Rawan; Chang, Janis; Chan, An‐Wen; Lilly, Leslie B.; Al Habeeb, Ayman; Rotstein, Coleman
- Abstract
Trichodysplasia spinulosa ( TS) is a rare dermatologic complication associated with the immunosuppressive therapy used in solid organ transplantation. The distinctive clinical manifestation of this condition is spiny follicular papules on the face, ears, extremities, and trunk. Histopathologically, abnormally maturing hair follicles with hyperkeratotic material are noted. The condition is produced by the trichodysplasia spinulosa-associated polyomavirus. Treatment of this condition in the past has entailed a reduction in immunosuppression, topical agents such as cidofovir or retinoids, or oral valganciclovir. Herein, we report a case of generalized TS treated successfully with leflunomide.
- Subjects
POLYOMAVIRUS diseases; LEFLUNOMIDE; LIVER transplantation; TRANSPLANTATION of organs, tissues, etc.; IMMUNOSUPPRESSION; VALGANCICLOVIR; THERAPEUTICS
- Publication
Transplant Infectious Disease, 2017, Vol 19, Issue 4, pn/a
- ISSN
1398-2273
- Publication type
Article
- DOI
10.1111/tid.12702