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- Title
Xanthohumol protects against Azoxymethane‐induced colorectal cancer in Sprague‐Dawley rats.
- Authors
Liu, Hualin; Zhang, Lei; Li, Guanghua; Gao, Zhuanglei
- Abstract
Colorectal cancer (CRC) is a major health problem and third most common deaths in western world. Dietary interventions together with modified dietary style can prevent the CRC in humans. Xanthohumol (XHA), a polyphenol isolated from Humulus lupulus L. contains many beneficial effects. The aim of the study is to analyze the effect of XHA on Azoxymethane (AOM)‐induced experimental CRC in rats. Levels of MDA were increased and enzymic antioxidants levels were decreased in AOM‐induced rats. However, these levels were reversed upon XHA treatment. Further, the mRNA expressions of iNOS and COX‐2 were also downregulated in XHA treated rats compared to AOM‐induced rats. Further, we found that administration of XHA suppressed the wnt/β‐catenin signaling together with modulation of apoptotic proteins Bax, Bcl‐2, and caspase 3. We conclude that XHA can able to quench the free radicals, inhibits cell proliferation and induces apoptosis, thus it can be a chemopreventive/therapeutic agent against CRC.
- Subjects
COLORECTAL cancer; RATS; HOPS; BAX protein; WESTERN countries; FREE radicals
- Publication
Environmental Toxicology, 2020, Vol 35, Issue 2, p136
- ISSN
1520-4081
- Publication type
Article
- DOI
10.1002/tox.22849