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- Title
Membrane-Accelerated Amyloid-β Aggregation and Formation of Cross-β Sheets.
- Authors
Khondker, Adree; Alsop, Richard J.; Rheinstädter, Maikel C.
- Abstract
Amyloid-β aggregates play a causative role in Alzheimer's disease. These aggregates are a product of the physical environment provided by the basic neuronal membrane, composed of a lipid bilayer. The intrinsic properties of the lipid bilayer allow amyloid-b peptides to nucleate and form well-ordered cross-β sheets within the membrane. Here, we correlate the aggregation of the hydrophobic fragment of the amyloid-β protein, Aβ25-35, with the hydrophobicity, fluidity, and charge density of a lipid bilayer. We summarize recent biophysical studies of model membranes and relate these to the process of aggregation in physiological systems.
- Subjects
ALZHEIMER'S disease treatment; AMYLOID; HYDROPHOBIC interactions; PEPTIDES; ARTIFICIAL membranes; THERAPEUTICS
- Publication
Membranes, 2017, Vol 7, Issue 3, p49
- ISSN
2077-0375
- Publication type
Article
- DOI
10.3390/membranes7030049