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- Title
Correlation Between the Movement Disorder Society's Unified Parkinson's Disease Rating Scale and Nonmotor Scales in Patients with Parkinson's Disease.
- Authors
DRIVER-DUNCKLEY, ERIKA D.; NAN ZHANG; SHILL, HOLLY A.; MEHTA, SHYAMAL H.; BELDEN, CHRISTINE M.; ZAMRINI, EDWARD Y.; DAVIS, KATHRYN; BEACH, THOMAS G.; ADLER, CHARLES H.
- Abstract
Background: The Movement Disorder Society's Unified Parkinson's Disease Rating Scale (MDSUPDRS), Scales for Outcomes in Parkinson's Disease--Autonomic (SCOPA-AUT), Mayo Sleep Questionnaire, Epworth Sleepiness Scale, and Neuropsychiatric Inventory Questionnaire (NPI-Q) are validated instruments for assessing signs and symptoms of Parkinson's disease (PD). Objective: We sought to determine whether responses on the MDS-UPDRS correlate with responses to other scales used in patients with PD. Design: Study subjects were enrolled in the Arizona Study of Aging and Neurodegenerative Disorders (AZSAND). Participants were selected if they had completed all scales within a one-month window. Spearman's rank correlation coefficients were calculated. Results: A total of 96 eligible subjects were identified. High correlation (r-values) was found between the SCOPA-AUT and MDS-UPDRS excessive saliva (0.73; p<0.001), constipation (0.62; p<0.001), and swallowing (0.59; p<0.001) questions. The r-values for the NPI-Q and MDS-UPDRS depression and anxiety questions were 0.53 (p<0.001), and 0.67 (p<0.001). Conclusion: MDS-UPDRS correlates well with some but not all questions from the SCOPA-AUT and NPI-Q. This work emphasizes the importance of employing multiple methods for assessing nonmotor symptoms in patients with PD.
- Subjects
PARKINSON'S disease diagnosis; AGING; ANXIETY; CONSTIPATION; STATISTICAL correlation; DEGLUTITION; MENTAL depression; NEURODEGENERATION; QUESTIONNAIRES; SALIVA; SLEEP; STATISTICS; DATA analysis; HUMAN research subjects; PATIENT selection; RESEARCH methodology evaluation
- Publication
Innovations in Clinical Neuroscience, 2019, Vol 16, Issue 9/10, p27
- ISSN
2158-8333
- Publication type
Article