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- Title
Pilot evaluation of anti-1-amino-2-[18F] fluorocyclopentane-1-carboxylic acid (anti-2-[18F] FACPC) PET-CT in recurrent prostate carcinoma.
- Authors
Savir-Baruch, Bital; Schuster, David; Jarkas, Nashwa; Master, Viraj; Nieh, Peter; Halkar, Raghuveer; Nye, Jonathon; Lewis, Melinda; Crowe, Ronald; Voll, Ronald; Camp, Vernon; Bellamy, Leah; Roberts, David; Goodman, Mark; Schuster, David M; Master, Viraj A; Nieh, Peter T; Halkar, Raghuveer K; Nye, Jonathon A; Lewis, Melinda M
- Abstract
<bold>Purpose: </bold>Anti-1-amino-2-[(18)F]fluorocyclopentane-1-carboxylic acid (anti-2-[(18)F]FACPC) is an unnatural alicyclic amino acid radiotracer with high uptake in the DU-145 prostate cancer cell line in vitro. Our goal was to determine if anti-2-[(18)F]FACPC is useful in the detection of prostate carcinoma.<bold>Procedures: </bold>Five patients with elevated PSA (1.1-20.5 ng/mL) after curative therapy for prostate carcinoma underwent 60 min dynamic positron emission tomography (PET) of the pelvis after IV injection of 193-340 MBq of anti-2-[(18)F]FACPC. Uptake was compared against PET scans in the same patients with the leucine analog, anti-1-amino-3-[(18)F]fluorocyclobutane-1-carboxylic acid (anti-[(18)F]FACBC), at similar time points and validated via pathology, clinical, and imaging follow-up.<bold>Results: </bold>At 5 min, average (±SD) SUVmax of malignant lesions is 4.1(±1.3) for anti-2-[(18)F] FACPC and 4.3(±1.1) for anti-[(18)F]FACBC. Yet, blood pool activity at 5 min is significantly higher for anti-2-[(18)F]FACPC with average (±SD) lesion/blood pool SUVmax/SUVmean ratio of 1.4 (±0.5) vs. 3.0 (±0.9) for anti-[(18)F]FACBC. At 20 min, average (±SD) SUVmax of malignant lesions is 2.6 (±1.0) for anti-2-[(18)F]FACPC and 3.4 (±0.8) for anti-[(18)F]FACBC. Yet, bladder activity at 20 min is significantly more intense for anti-2-[(18)F] FACPC with average (±SD) lesion/bladder SUVmax/SUVmean ratio of 0.3 (±0.8) vs. 2.3 (±1.4) for anti-[(18)F]FACBC.<bold>Conclusions: </bold>While prostate bed lesions are visible on early imaging with anti-2-[(18)F]FACPC, there is high blood pool activity obscuring nodes. As blood pool fades, nodal uptake decreases and high bladder activity then obscures pelvic structures. Compared with anti-[(18)F]FACBC, imaging characteristics for anti-2-[(18)F]FACPC are unfavorable for pelvic recurrent prostate carcinoma detection.
- Subjects
CARBOXYLIC acids; POSITRON emission tomography; PROSTATE cancer; CANCER treatment; CANCER diagnosis; PELVIC radiography; BIOPSY; COMPARATIVE studies; COMPUTED tomography; DIAGNOSTIC imaging; FLUORINE isotopes; RESEARCH methodology; MEDICAL cooperation; PROSTATE tumors; RADIOISOTOPES; RESEARCH; RESEARCH funding; TIME; DISEASE relapse; PILOT projects; EVALUATION research
- Publication
Molecular Imaging & Biology, 2011, Vol 13, Issue 6, p1272
- ISSN
1536-1632
- Publication type
journal article
- DOI
10.1007/s11307-010-0445-3