We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Pediatric Liver Transplantation.
- Authors
Kocoshis, Samuel A.; Tzakis, Andreas; Todo, Satoru; Reyes, Jorge; Nour, Bakr
- Abstract
Pediatric liver transplantation has advanced remarkably over the past three decades. One-year survival has progressively increased to nearly 90% in patients transplanted for most forms of liver disease. Parallel advances in organ procurement, operative technique, immunosuppression, and infection control are responsible for improved patient survival. Among the most important advances are use of the University of Wisconsin (UW) organ preservation solution, the employment of venovenous bypass and/or "piggyback" operative technique, the development of cyclosporine A (CyA) and FK506, and the emergence of acyclovir, ganciclovir, foscarnet, and alpha interferon to combat life-threatening viral infections, The current organ shortage is being addressed by "cutdown" liver transplantation, "split liver" transplantation, and living-related donations. The next decade is likely to see advances in multivisceral transplantation, induction of chimerism by simultaneous bone marrow-solid organ transplantation, and performance of cross-species xenografting.
- Subjects
LIVER transplantation; PEDIATRICS; ORGAN donation; IMMUNOREGULATION; GANCICLOVIR; ANTINEOPLASTIC agents
- Publication
Clinical Pediatrics, 1993, Vol 32, Issue 7, p386
- ISSN
0009-9228
- Publication type
Article
- DOI
10.1177/000992289303200701