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- Title
Hereditary Cancer Syndromes: A Comprehensive Review with a Visual Tool.
- Authors
Garutti, Mattia; Foffano, Lorenzo; Mazzeo, Roberta; Michelotti, Anna; Da Ros, Lucia; Viel, Alessandra; Miolo, Gianmaria; Zambelli, Alberto; Puglisi, Fabio
- Abstract
Hereditary cancer syndromes account for nearly 10% of cancers even though they are often underdiagnosed. Finding a pathogenic gene variant could have dramatic implications in terms of pharmacologic treatments, tailored preventive programs, and familiar cascade testing. However, diagnosing a hereditary cancer syndrome could be challenging because of a lack of validated testing criteria or because of their suboptimal performance. In addition, many clinicians are not sufficiently well trained to identify and select patients that could benefit from a genetic test. Herein, we searched the available literature to comprehensively review and categorize hereditary cancer syndromes affecting adults with the aim of helping clinicians in their daily clinical practice through a visual tool.
- Subjects
HEREDITARY cancer syndromes; GENETIC variation; GENETIC testing; CANCER genetics
- Publication
Genes, 2023, Vol 14, Issue 5, p1025
- ISSN
2073-4425
- Publication type
Article
- DOI
10.3390/genes14051025