We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Nutrition-Related Outcomes for Autologous Stem Cell Transplantation Patients.
- Authors
Lazarow, Heather; Nicolo, Michele; Compher, Charlene; Kucharczuk, Colleen R.; Stadtmauer, Edward A.; Landsburg, Daniel J.
- Abstract
<bold>Introduction: </bold>Autologous stem cell transplantation (ASCT) patients are at risk for malnutrition before transplantation admission as well as malnutrition acquired during their transplantation admission.<bold>Patients and Methods: </bold>In this retrospective, observational study we examined data related to consecutive adults (n = 330) admitted for ASCT between 2014 and 2016 at the Hospital of the University of Pennsylvania. Malnutrition risk on admission (identified by the Malnutrition Screening Tool) and transplantation-associated weight loss were analyzed for independent associations with hospital length of stay, nosocomial infection, intensive care unit transfer, deconditioning, time to platelet and neutrophil engraftment, 30-day readmission, and 1-year mortality.<bold>Results: </bold>Adults with high malnutrition risk (n = 60) had a longer median hospital stay (P = .004), longer median time to platelet engraftment (P = .022), increased nosocomial infections (P = .047), and increased 1-year mortality (P = .036). Adults with high transplantation-associated weight loss (n = 100) experienced longer hospital stays (P < .001) and more intensive care unit transfers (P = .001). Outcomes for deconditioning, time to neutrophil engraftment, and 30-day readmission did not differ significantly on the basis of nutrition risk or weight loss.<bold>Conclusion: </bold>Further research is needed to determine whether early nutrition intervention would improve these outcomes.
- Subjects
NUTRITIONAL assessment; RETROSPECTIVE studies; TREATMENT effectiveness; AUTOGRAFTS; MALNUTRITION; RESEARCH funding; HEMATOPOIETIC stem cell transplantation; NUTRITIONAL status
- Publication
Clinical Lymphoma, Myeloma & Leukemia, 2019, Vol 19, Issue 7, pe393
- ISSN
2152-2650
- Publication type
journal article
- DOI
10.1016/j.clml.2019.04.002