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- Title
Clear cell urothelial carcinoma: A clinicopathological study of nine cases and review of the literature.
- Authors
Bateman, Justin; Wasserman, Jason K.; Flood, Trevor A.; Djordjevic, Bojana; Belanger, Eric C.; Mai, Kien T.
- Abstract
Objective: Clear cell urothelial carcinoma (CCUC) is a rare variant of urothelial carcinoma (UC). The objective of this study was to examine its clinical significance. Methods: Consecutive cases of UC from our institution were reviewed to identify cases of CCUC. Characteristics recorded included: proportion of tumour cells with clear cell change, patterns of the intra-urothelial and invasive tumour components, tumour stage, and the original diagnosis rendered. Clinical information including patient sex, age, and outcome were abstracted. A review of the medical literature was conducted for reported cases. Results:We found nine cases of CCUC at our institution. They were high-grade and exhibited distinctive clear cytoplasm. Clear cell component accounted for 30-90% of the tumour. Of the nine cases, one was originally diagnosed as a nested variant and three as conventional invasive UC. A literature review revealed 28 reported cases of CCUC. A comparison of our series versus the reported cases showed: a) male predominance with ratio of M:F=9:0 vs. 4:1 and mean age of 70±8 vs. 67±9, b) clinical stage pT3-4 in 7/9 (79%) vs. 5/8 (63%), and c) patient death or survival with disease in a high proportion of cases, 3/9 (33%) vs. 4/12 (33%), respectively. Conclusions: This cohort of CCUC represents the largest case series to date. CCUC can be distinguished from non-CCUC by the extensive clear cell change in more than 30% of cells, and is often under-diagnosed. This variant is associated with male predominance and an aggressive clinical course.
- Publication
Canadian Journal of Pathology, 2016, Vol 8, p32
- ISSN
1918-915X
- Publication type
Article