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- Title
Retrospective analysis of patients with relapsed/refractory medulloblastoma after autologous stem cell transplantation.
- Authors
Acar, Ramazan; Ertürk, İsmail; Kızılöz, Halil; Okçelik, Sezgin; Yıldız, Birol; Aykan, Musa Barış; Yıldıran Keskin, Gül Sema; Sertoğlu, Erdim; Başgöz, Bilgin Bahadır; Karadurmuş, Nuri
- Abstract
Aims: Medulloblastoma is very rare and accounts for only 1% of intracranial tumors in adults. There are limited treatment options for adult medulloblastoma patients who have relapsed or refractory disease. We aimed to show real-life data on health outcomes in adult patients with recurrent or refractory medulloblastoma patients who received autologous hematopoietic stem cell transplantation (AHSCT). Methods: We analyzed the data of 15 patients who underwent AHSCT after ifosfamide, carboplatin, and etoposide (ICE) as high-dose chemotherapy (HDCT) regimen for relapsed or refractory medulloblastoma from 2010 to 2020. Overall response rate (ORR), overall survival (OS) and progression-free survival (PFS) of the patients were evaluated. Results: Fifteen patients were observed in this study. The mean age of the study group was 27.9±8.1 years and 53.3% of the patients were female (n=8). ORR was 100%. The median OS and PFS were 24 months [95% confidence interval (CI): 11.4-36.5] and 13 months (95% CI: 10.2- 15.8), respectively. One-year OS and PFS rates were 77% and 55.2%, respectively. Five-year OS rate was 82.5%. Conclusions: AHSCT with ICE as HDCT regimen is a safe and effective treatment option for relapsed or refractory adult medulloblastoma patients with an acceptable ORR, OS and PFS time.
- Subjects
MEDULLOBLASTOMA; HEMATOPOIETIC stem cell transplantation; CANCER chemotherapy
- Publication
Gulhane Medical Journal, 2020, Vol 62, Issue 4, p266
- ISSN
1302-0471
- Publication type
Article
- DOI
10.4274/gulhane.galenos.2020.1180