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- Title
EVALUATION OF SKIN PARAMETERS CHANGES IN CHEMICAL AND PHOTOCHEMICAL INITIATED TUMORS ON SKH1 MICE.
- Authors
Ciurlea, Sorina; Maria-Florina Bojin; Csanyi, Erzebet; Ionescu, Daniela; Borcan, Florin; Galuscan, Atena; Dehelean, Cristina A.
- Abstract
Ultraviolet B (UVB) or medium wave irradiation, with a wavelength in the range 315-280 nm and a energy per photon between 3.94-4.43 eV, regulates ultraviolet-responsive genes, including matrix metalloproteinases. Moreover, it causes connective tissue damage and the skin to become wrinkled and aged. The aim of this study was to investigate the evolution of the mouse skin papillomas initiated by 7,12-dimethylbenzanthracene (DMBA) and promoted by 12-O-decanoylphorbol-13-acetate (TPA), which progressed more rapidly to carcinoma on mice exposed to UVB. The biological effects of these two tumors (chemically and photochemically initiated) were evaluated for twelve weeks on the SKH1 hairless mice skin by using of non-invasive techniques (tewameter, skin-pH-meter, melanin and erythema measurements). It was found that UVB irradiation affects very much the parameters which were monitored and which characterizing the skin condition.
- Subjects
PHYSIOLOGICAL effects of ultraviolet radiation; SKIN physiology; PAPILLOMA; 7,12-Dimethylbenzanthracene; PHOTONS; LABORATORY mice
- Publication
Physiology / Fiziologia, 2011, Vol 21, Issue 3, p18
- ISSN
1223-2076
- Publication type
Article