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- Title
KINETICS OF ZOLPIDEM AND ITS METABOLITE AFTER SINGLE DOSE ORAL ADMINISTRATION.
- Authors
GHELDIU, ANA-MARIA; CSAVDARI, ALEXANDRA; ACHIM, MARCELA; VLASE, LAURIAN; TOMUȚĂ, IOAN; MUNTEAN, DANA MARIA
- Abstract
The present study aimed to describe the basic pharmacokinetics of zolpidem and its metabolite zolpidem phenyl-4-carboxylic acid after a single oral dose of 5 mg zolpidem. Six competing kinetic models were created in order to analyze the experimental data obtained from the 20 healthy volunteers enrolled in a clinical study. Based on rational model discrimination criteria (Akaike index value), the best one was chosen and further used for a better understanding of the kinetics of zolpidem and its metabolite in the body after administration. The kinetic model considers that zolpidem absorption process follows a first-order kinetics and during this stage it is partially metabolized (pre-systemic metabolism) to its main metabolite. The kinetics of both zolpidem and its metabolite is characterized by bicompartmental distribution and first order kinetics of both elimination and systemic metabolism.
- Subjects
ZOLPIDEM; PHARMACOKINETICS; METABOLITES; DRUG dosage; ORAL drug administration
- Publication
Studia Universitatis Babes-Bolyai, Chemia, 2017, Vol 62, Issue 2, Tom 2, p179
- ISSN
1224-7154
- Publication type
Article
- DOI
10.24193/subbchem.2017.2.13