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The Kalimantacin Polyketide Antibiotics Inhibit Fatty Acid Biosynthesis in Staphylococcus aureus by Targeting the Enoyl‐Acyl Carrier Protein Binding Site of FabI.
Published in:
Angewandte Chemie, 2020, v. 132, n. 26, p. 10636, doi. 10.1002/ange.201915407
By:
- Fage, Christopher D.;
- Lathouwers, Thomas;
- Vanmeert, Michiel;
- Gao, Ling‐Jie;
- Vrancken, Kristof;
- Lammens, Eveline‐Marie;
- Weir, Angus N. M.;
- Degroote, Ruben;
- Cuppens, Harry;
- Kosol, Simone;
- Simpson, Thomas J.;
- Crump, Matthew P.;
- Willis, Christine L.;
- Herdewijn, Piet;
- Lescrinier, Eveline;
- Lavigne, Rob;
- Anné, Jozef;
- Masschelein, Joleen
Publication type:
Article
Control of β‐Branching in Kalimantacin Biosynthesis: Application of <sup>13</sup>C NMR to Polyketide Programming.
Published in:
Angewandte Chemie, 2019, v. 131, n. 36, p. 12576, doi. 10.1002/ange.201905482
By:
- Walker, Paul D.;
- Williams, Christopher;
- Weir, Angus N. M.;
- Wang, Luoyi;
- Crosby, John;
- Race, Paul R.;
- Simpson, Thomas J.;
- Willis, Christine L.;
- Crump, Matthew P.
Publication type:
Article
Selected Mutations Reveal New Intermediates in the Biosynthesis of Mupirocin and the Thiomarinol Antibiotics.
Published in:
Angewandte Chemie, 2017, v. 129, n. 14, p. 3988, doi. 10.1002/ange.201611590
By:
- Gao, Shu ‐ Shan;
- Wang, Luoyi;
- Song, Zhongshu;
- Hothersall, Joanne;
- Stevens, Elton R.;
- Connolly, Jack;
- Winn, Peter J.;
- Cox, Russell J.;
- Crump, Matthew P.;
- Race, Paul R.;
- Thomas, Christopher M.;
- Simpson, Thomas J.;
- Willis, Christine L.
Publication type:
Article
Rücktitelbild: Selected Mutations Reveal New Intermediates in the Biosynthesis of Mupirocin and the Thiomarinol Antibiotics (Angew. Chem. 14/2017).
Published in:
Angewandte Chemie, 2017, v. 129, n. 14, p. 4126, doi. 10.1002/ange.201702123
By:
- Gao, Shu ‐ Shan;
- Wang, Luoyi;
- Song, Zhongshu;
- Hothersall, Joanne;
- Stevens, Elton R.;
- Connolly, Jack;
- Winn, Peter J.;
- Cox, Russell J.;
- Crump, Matthew P.;
- Race, Paul R.;
- Thomas, Christopher M.;
- Simpson, Thomas J.;
- Willis, Christine L.
Publication type:
Article
Heterologe Produktion pilzlicher Maleidride enthüllt die kryptische Cyclisierung in ihrer Biosynthese.
Published in:
Angewandte Chemie, 2016, v. 128, n. 23, p. 6896, doi. 10.1002/ange.201511882
By:
- Williams, Katherine;
- Szwalbe, Agnieszka J.;
- Mulholland, Nicholas P.;
- Vincent, Jason L.;
- Bailey, Andrew M.;
- Willis, Christine L.;
- Simpson, Thomas J.;
- Cox, Russell J.
Publication type:
Article
Methods for the synthesis of carbon-13 labelled acids and esters.
Published in:
Journal of Labelled Compounds & Radiopharmaceuticals, 2007, v. 50, n. 5/6, p. 338, doi. 10.1002/jlcr.1198
By:
- Jordan, Angela C.;
- Axford, Lorraine C.;
- Harding, John R.;
- O'Connell, Yvonne;
- Simpson, Thomas J.;
- Willis, Christine L.
Publication type:
Article
A New Antioxidant Triterpenoid from the Stem Wood of Sorbus lanata.
Published in:
Records of Natural Products, 2014, v. 8, n. 1, p. 19
By:
- Latif, Abdul;
- Hussain, Syed Hamid;
- Ali, Mumtaz;
- Arfan, Mohammad;
- Ahmed, Manzoor;
- Cox, Russell J.;
- Simpson, Thomas J.;
- Uddin, Ghias
Publication type:
Article
Back Cover: Selected Mutations Reveal New Intermediates in the Biosynthesis of Mupirocin and the Thiomarinol Antibiotics (Angew. Chem. Int. Ed. 14/2017).
Published in:
Angewandte Chemie International Edition, 2017, v. 56, n. 14, p. 4066, doi. 10.1002/anie.201702123
By:
- Gao, Shu-Shan;
- Wang, Luoyi;
- Song, Zhongshu;
- Crump, Matthew P.;
- Simpson, Thomas J.;
- Willis, Christine L.;
- Cox, Russell J.;
- Hothersall, Joanne;
- Stevens, Elton R.;
- Connolly, Jack;
- Winn, Peter J.;
- Thomas, Christopher M.;
- Race, Paul R.
Publication type:
Article
Selected Mutations Reveal New Intermediates in the Biosynthesis of Mupirocin and the Thiomarinol Antibiotics.
Published in:
Angewandte Chemie International Edition, 2017, v. 56, n. 14, p. 3930, doi. 10.1002/anie.201611590
By:
- Gao, Shu-Shan;
- Wang, Luoyi;
- Song, Zhongshu;
- Crump, Matthew P.;
- Simpson, Thomas J.;
- Willis, Christine L.;
- Cox, Russell J.;
- Hothersall, Joanne;
- Stevens, Elton R.;
- Connolly, Jack;
- Winn, Peter J.;
- Thomas, Christopher M.;
- Race, Paul R.
Publication type:
Article
Heterologous Production of Fungal Maleidrides Reveals the Cryptic Cyclization Involved in their Biosynthesis.
Published in:
Angewandte Chemie International Edition, 2016, v. 55, n. 23, p. 6784, doi. 10.1002/anie.201511882
By:
- Williams, Katherine;
- Szwalbe, Agnieszka J.;
- Mulholland, Nicholas P.;
- Vincent, Jason L.;
- Bailey, Andrew M.;
- Willis, Christine L.;
- Simpson, Thomas J.;
- Cox, Russell J.
Publication type:
Article
The Biosynthesis and Catabolism of the Maleic Anhydride Moiety of Stipitatonic Acid.
Published in:
Angewandte Chemie International Edition, 2014, v. 53, n. 29, p. 7519, doi. 10.1002/anie.201403450
By:
- al Fahad, Ahmed;
- Abood, Amira;
- Simpson, Thomas J.;
- Cox, Russell J.
Publication type:
Article
The Biosynthesis and Catabolism of the Maleic Anhydride Moiety of Stipitatonic Acid.
Published in:
Angewandte Chemie, 2014, v. 126, n. 29, p. 7649, doi. 10.1002/ange.201403450
By:
- al Fahad, Ahmed;
- Abood, Amira;
- Simpson, Thomas J.;
- Cox, Russell J.
Publication type:
Article
Engineered Thiomarinol Antibiotics Active against MRSA Are Generated by Mutagenesis and Mutasynthesis of Pseudoalteromonas SANK73390.
Published in:
Angewandte Chemie, 2011, v. 123, n. 14, p. 3329, doi. 10.1002/ange.201007029
By:
- Murphy, Annabel C.;
- Fukuda, Daisuke;
- Song, Zhongshu;
- Hothersall, Joanne;
- Cox, Russell J.;
- Willis, Christine L.;
- Thomas, Christopher M.;
- Simpson, Thomas J.
Publication type:
Article
The prenatal determination of glucose-6-phosphatase activity by fetal liver biopsy.
Published in:
Prenatal Diagnosis, 1988, v. 8, n. 6, p. 401, doi. 10.1002/pd.1970080603
By:
- Golbus, Mitchell S.;
- Simpson, Thomas J.;
- Koresawa, Mitsuhiko;
- Appelman, Zvi;
- Alpers, Charles E.
Publication type:
Article
Ontogeny of fetal liver glucose-6-phosphatase activity.
Published in:
1987
By:
- Simpson, Thomas J.;
- Koresawa, Mitsuhiko;
- Hogge, W. Allen;
- Holzgreve, Wolfgang;
- Golbus, Mitchell S.;
- Simpson, T J;
- Koresawa, M;
- Hogge, W A;
- Holzgreve, W;
- Golbus, M S
Publication type:
journal article
Manipulation of quorum sensing regulation in Pseudomonas fluorescens NCIMB 10586 to increase mupirocin production.
Published in:
Applied Microbiology & Biotechnology, 2011, v. 90, n. 3, p. 1017, doi. 10.1007/s00253-011-3145-2
By:
- Hothersall, Joanne;
- Murphy, Annabel C.;
- Iqbal, Zafar;
- Campbell, Genevieve;
- Stephens, Elton R.;
- Ji'en Wu;
- Cooper, Helen;
- Atkinson, Steve;
- Williams, Paul;
- Crosby, John;
- Willis, Christine L.;
- Cox, Russell J.;
- Simpson, Thomas J.;
- Thomas, Christopher M.
Publication type:
Article
A Natural Plasmid Uniquely Encodes Two Biosynthetic Pathways Creating a Potent Anti-MRSA Antibiotic.
Published in:
PLoS ONE, 2011, v. 6, n. 3, p. 1, doi. 10.1371/journal.pone.0018031
By:
- Fukuda, Daisuke;
- Haines, Anthony S.;
- Song, Zhongshu;
- Murphy, Annabel C.;
- Hothersall, Joanne;
- Stephens, Elton R.;
- Gurney, Rachel;
- Cox, Russell J.;
- Crosby, John;
- Willis, Christine L.;
- Simpson, Thomas J.;
- Thomas, Christopher M.
Publication type:
Article
Fine Tuning of Antibiotic Activity by a Tailoring Hydroxylase in a Trans‐AT Polyketide Synthase Pathway.
Published in:
ChemBioChem, 2018, v. 19, n. 8, p. 836, doi. 10.1002/cbic.201800036
By:
- Mohammad, Hadi H.;
- Connolly, Jack A.;
- Song, Zhongshu;
- Hothersall, Joanne;
- Race, Paul R.;
- Willis, Christine L.;
- Simpson, Thomas J.;
- Winn, Peter J.;
- Thomas, Christopher M.
Publication type:
Article
Genetic and Biosynthetic Studies of the Fungal Prenylated Xanthone Shamixanthone and Related Metabolites in Aspergillus spp. Revisited.
Published in:
ChemBioChem, 2012, v. 13, n. 11, p. 1680, doi. 10.1002/cbic.201200014
By:
- Simpson, Thomas J.
Publication type:
Article
First Heterologous Reconstruction of a Complete Functional Fungal Biosynthetic Multigene Cluster.
Published in:
ChemBioChem, 2010, v. 11, n. 11, p. 1508, doi. 10.1002/cbic.201000259
By:
- Heneghan, Mary N.;
- Yakasai, Ahmed A.;
- Halo, Laura M.;
- Song, Zhongshu;
- Bailey, Andrew M.;
- Simpson, Thomas J.;
- Cox, Russell J.;
- Lazarus, Colin M.
Publication type:
Article
Structure and Function of the α‐Hydroxylation Bimodule of the Mupirocin Polyketide Synthase.
Published in:
Angewandte Chemie, 2023, v. 135, n. 47, p. 1, doi. 10.1002/ange.202312514
By:
- Winter, Ashley J.;
- Khanizeman, R. Nisha;
- Barker‐Mountford, Abigail M. C.;
- Devine, Andrew J.;
- Wang, Luoyi;
- Song, Zhongshu;
- Davies, Jonathan A.;
- Race, Paul R.;
- Williams, Christopher;
- Simpson, Thomas J.;
- Willis, Christine L.;
- Crump, Matthew P.
Publication type:
Article
Structure and Function of the α‐Hydroxylation Bimodule of the Mupirocin Polyketide Synthase.
Published in:
Angewandte Chemie International Edition, 2023, v. 62, n. 47, p. 1, doi. 10.1002/anie.202312514
By:
- Winter, Ashley J.;
- Khanizeman, R. Nisha;
- Barker‐Mountford, Abigail M. C.;
- Devine, Andrew J.;
- Wang, Luoyi;
- Song, Zhongshu;
- Davies, Jonathan A.;
- Race, Paul R.;
- Williams, Christopher;
- Simpson, Thomas J.;
- Willis, Christine L.;
- Crump, Matthew P.
Publication type:
Article
The Kalimantacin Polyketide Antibiotics Inhibit Fatty Acid Biosynthesis in Staphylococcus aureus by Targeting the Enoyl‐Acyl Carrier Protein Binding Site of FabI.
Published in:
Angewandte Chemie International Edition, 2020, v. 59, n. 26, p. 10549, doi. 10.1002/anie.201915407
By:
- Fage, Christopher D.;
- Lathouwers, Thomas;
- Vanmeert, Michiel;
- Gao, Ling‐Jie;
- Vrancken, Kristof;
- Lammens, Eveline‐Marie;
- Weir, Angus N. M.;
- Degroote, Ruben;
- Cuppens, Harry;
- Kosol, Simone;
- Simpson, Thomas J.;
- Crump, Matthew P.;
- Willis, Christine L.;
- Herdewijn, Piet;
- Lescrinier, Eveline;
- Lavigne, Rob;
- Anné, Jozef;
- Masschelein, Joleen
Publication type:
Article
Control of β‐Branching in Kalimantacin Biosynthesis: Application of <sup>13</sup>C NMR to Polyketide Programming.
Published in:
Angewandte Chemie International Edition, 2019, v. 58, n. 36, p. 12446, doi. 10.1002/anie.201905482
By:
- Walker, Paul D.;
- Williams, Christopher;
- Weir, Angus N. M.;
- Wang, Luoyi;
- Crosby, John;
- Race, Paul R.;
- Simpson, Thomas J.;
- Willis, Christine L.;
- Crump, Matthew P.
Publication type:
Article
Synthesis and Incorporation of the First Polyketide Synthase Free Intermediate in Monocerin Biosynthesis ( We thank the Engineering and Physical Sciences Research Council for support (GR/N21352) and for a research studentship (L.C.A.), and Dr. M. P. Crump for a 600 MHz NMR spectrum. )
Published in:
Angewandte Chemie, 2004, v. 116, n. 6, p. 745, doi. 10.1002/ange.200352652
By:
- Lorraine C. Axford;
- Thomas J. Simpson;
- Christine L. Willis
Publication type:
Article
Ultraviolet-Irradiated Urocanic Acid Suppresses Delayed-Type Hypersensitivity to Herpes Simplex Virus in Mice.
Published in:
Journal of Investigative Dermatology, 1986, v. 87, n. 5, p. 630, doi. 10.1111/1523-1747.ep12456257
By:
- Ross, James A.;
- Howie, Sarah E. M.;
- Norval, Mary;
- Maingay, Jean;
- Simpson, Thomas J.
Publication type:
Article
Resistance to and synthesis of the antibiotic mupirocin.
Published in:
Nature Reviews Microbiology, 2010, v. 8, n. 4, p. 281, doi. 10.1038/nrmicro2278
By:
- Thomas, Christopher M.;
- Hothersall, Joanne;
- Willis, Christine L.;
- Simpson, Thomas J.
Publication type:
Article
Strobilurin biosynthesis in Basidiomycete fungi.
Published in:
Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-06202-4
By:
- Nofiani, Risa;
- de Mattos-Shipley, Kate;
- Lebe, Karen E.;
- Han, Li-Chen;
- Iqbal, Zafar;
- Bailey, Andrew M.;
- Willis, Christine L.;
- Simpson, Thomas J.;
- Cox, Russell J.
Publication type:
Article
Synthesis and Incorporation of the First Polyketide Synthase Free Intermediate in Monocerin Biosynthesis ( We thank the Engineering and Physical Sciences Research Council for support (GR/N21352) and for a research studentship (L.C.A.), and Dr. M. P. Crump for a 600 MHz NMR spectrum. )
Published in:
Angewandte Chemie International Edition, 2004, v. 43, n. 6, p. 727, doi. 10.1002/anie.200352652
By:
- Lorraine C. Axford;
- Thomas J. Simpson;
- Christine L. Willis
Publication type:
Article
Defining the genes for the final steps in biosynthesis of the complex polyketide antibiotic mupirocin by Pseudomonas fluorescens NCIMB10586.
Published in:
Scientific Reports, 2019, v. 9, n. 1, p. 1, doi. 10.1038/s41598-018-38038-9
By:
- Connolly, Jack A.;
- Wilson, Amber;
- Macioszek, Malgorzata;
- Song, Zhongshu;
- Wang, Luoyi;
- Mohammad, Hadi H.;
- Yadav, Mukul;
- di Martino, Maura;
- Miller, Claire E.;
- Hothersall, Joanne;
- Haines, Anthony S.;
- Stephens, Elton R.;
- Crump, Matthew P.;
- Willis, Christine L.;
- Simpson, Thomas J.;
- Winn, Peter J.;
- Thomas, Christopher M.
Publication type:
Article
A conserved motif flags acyl carrier proteins for β-branching in polyketide synthesis.
Published in:
Nature Chemical Biology, 2013, v. 9, n. 11, p. 685, doi. 10.1038/nchembio.1342
By:
- Haines, Anthony S;
- Dong, Xu;
- Song, Zhongshu;
- Farmer, Rohit;
- Williams, Christopher;
- Hothersall, Joanne;
- Płoskoń, Eliza;
- Wattana-amorn, Pakorn;
- Stephens, Elton R;
- Yamada, Erika;
- Gurney, Rachel;
- Takebayashi, Yuiko;
- Masschelein, Joleen;
- Cox, Russell J;
- Lavigne, Rob;
- Willis, Christine L;
- Simpson, Thomas J;
- Crosby, John;
- Winn, Peter J;
- Thomas, Christopher M
Publication type:
Article
Phosphopantetheinylation and Specificity of Acyl Carrier Proteins in the Mupirocin Biosynthetic Cluster.
Published in:
ChemBioChem, 2010, v. 11, n. 2, p. 248, doi. 10.1002/cbic.200900565
By:
- Shields, Jennifer A.;
- Rahman, Ayesha S.;
- Arthur, Christopher J.;
- Crosby, John;
- Hothersall, Joanne;
- Simpson, Thomas J.;
- Thomas, Christopher M.
Publication type:
Article
An ACP Structural Switch: Conformational Differences between the Apo and Holo Forms of the Actinorhodin Polyketide Synthase Acyl Carrier Protein.
Published in:
ChemBioChem, 2008, v. 9, n. 15, p. 2424, doi. 10.1002/cbic.200800180
By:
- Evans, Simon E.;
- Williams, Christopher;
- Arthur, Christopher J.;
- Burston, Steven G.;
- Simpson, Thomas J.;
- Crosby, John;
- Crump, Matthew P.
Publication type:
Article
In vivo Mutational Analysis of the Mupirocin Gene Cluster Reveals Labile Points in the Biosynthetic Pathway: the 'Leaky Hosepipe' Mechanism.
Published in:
ChemBioChem, 2008, v. 9, n. 9, p. 1500, doi. 10.1002/cbic.200800085
By:
- Wu, Ji'en;
- Hothersall, Joanne;
- Mazzetti, Carlo;
- O'Connell, Yvonne;
- Shields, Jennifer A.;
- Rahman, Ayesha S.;
- Cox, Russell J.;
- Crosby, John;
- Simpson, Thomas J.;
- Thomas, Christopher M.;
- Willis, Christine L.
Publication type:
Article
Authentic Heterologous Expression of the Tenellin Iterative Polyketide Synthase Nonribosomal Peptide Synthetase Requires Coexpression with an Enoyl Reductase.
Published in:
ChemBioChem, 2008, v. 9, n. 4, p. 585, doi. 10.1002/cbic.200700390
By:
- Halo, Laura M.;
- Marshall, James W.;
- Yakasai, Ahmed A.;
- Song, Zhongshu;
- Butts, Craig P.;
- Crump, Matthew P.;
- Heneghan, Mary;
- Bailey, Andrew M.;
- Simpson, Thomas J.;
- Lazarus, Colin. M.;
- Cox, Russell J.
Publication type:
Article
Biosynthesis of the 2-Pyridone Tenellin in the Insect Pathogenic Fungus Beauveria bassiana.
Published in:
ChemBioChem, 2007, v. 8, n. 3, p. 289, doi. 10.1002/cbic.200600398
By:
- Eley, Kirstin L.;
- Halo, Laura M.;
- Song, Zhongshu;
- Powles, Henry;
- Cox, Russell J.;
- Bailey, Andrew M.;
- Lazarus, Colin M.;
- Simpson, Thomas J.
Publication type:
Article
Synthesis of [1,2-13C2,15N]-L-Homoserine and Its Incorporation by the PKS-NRPS System of Fusarium moniliforme into the Mycotoxin Fusarin C.
Published in:
ChemBioChem, 2007, v. 8, n. 1, p. 46, doi. 10.1002/cbic.200600404
By:
- David O. Rees;
- Nick Bushby;
- Russell J. Cox;
- John R. Harding;
- Thomas J. Simpson;
- Christine L. Willis
Publication type:
Article
Catalytic Relationships between Type I and Type II Iterative Polyketide Synthases: The Aspergillus parasiticus Norsolorinic Acid Synthase.
Published in:
ChemBioChem, 2006, v. 7, n. 12, p. 1951, doi. 10.1002/cbic.200600341
By:
- Ma, Yue;
- Smith, Leah H.;
- Cox, Russell J.;
- Beltran-Alvarez, Pedro;
- Arthur, Christopher J.;
- Simpson, Thomas J.
Publication type:
Article
Fusarin C Biosynthesis in Fusarium moniliforme and Fusarium venenatum.
Published in:
ChemBioChem, 2004, v. 5, n. 9, p. 1196, doi. 10.1002/cbic.200400138
By:
- Zhongshu Song;
- Russell J. Cox;
- Colin M. Lazarus;
- Thomas J. Simpson
Publication type:
Article
Synthesis and Characterisation of Acyl Carrier Protein Bound Polyketide Analogues.
Published in:
ChemBioChem, 2002, v. 3, n. 2/3, p. 253, doi. 10.1002/1439-7633(20020301)3:2/3<253::AID-CBIC253>3.0.CO;2-7
By:
- Arthur, Christopher;
- Cox, Russell J.;
- Crosby, John;
- Rahman, Mujiber M.;
- Simpson, Thomas J.;
- Soulas, Florilene;
- Spogli, Roberto;
- Szafranska, Anna E.;
- Westcott, James;
- Winfield, Christopher J.
Publication type:
Article
A Chain initiation factor common to both modular and aromatic polyketide synthases.
Published in:
Nature, 1999, v. 401, n. 6752, p. 502, doi. 10.1038/46829
By:
- Bisang, Christian;
- Long, Paul F.;
- Cortes, Jesus;
- Westcott, James;
- Crosby, John;
- Matharu, Anne-Lise;
- Cox, Russell J.;
- Simpson, Thomas J.;
- Staunton, James;
- Leadlay, Peter F.
Publication type:
Article
Engineered Thiomarinol Antibiotics Active against MRSA Are Generated by Mutagenesis and Mutasynthesis of Pseudoalteromonas SANK73390.
Published in:
Angewandte Chemie International Edition, 2011, v. 50, n. 14, p. 3271, doi. 10.1002/anie.201007029
By:
- Murphy, Annabel C.;
- Fukuda, Daisuke;
- Song, Zhongshu;
- Hothersall, Joanne;
- Cox, Russell J.;
- Willis, Christine L.;
- Thomas, Christopher M.;
- Simpson, Thomas J.
Publication type:
Article

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