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- Title
Evaluating a Variable Porosity Wound Dressing With Anti-Scar Properties in a Porcine Model of Wound Healing.
- Authors
Woeller, Collynn F.; Woodroof, Aubrey; Lacy, Shannon H.; Cottler, Patrick S.; Gui, Jane L.; Pineros-Fernandez, Angela; Pollock, Stephen J.; Phipps, Richard P.
- Abstract
Introduction: Newtreatments that promotewound healingwhile preventing scar formation are needed. One option in topical wound healing is the use of temporary dressings that allow the natural healing process with minimal scar formation. Methods: We evaluated the temporary wound dressings PermeaDerm C, and a PermeaDerm C derivative coated with the anti-scarring agent, salinomycin (PermeaDerm D) in a pig model of wound healing to show the efficacy of these wound dressings in vivo. Results: Porcine fibroblasts grow well in the presence of PermeaDerm C or PermeaDerm A, and salinomycin reduces excessive myofibroblast formation in porcine fibroblasts in vitro. In vivo, wounds treated with PermeaDerm C and PermeaDerm A did not show abnormal or unwanted healing patterns up to 8 weeks post-wound formation. Wounds covered with either PermeaDerm C or PermeaDerm A showed a more mature wound-healing phenotype than the control wounds. Conclusions: PermeaDerm C and PermeaDerm A allowed wound healing, revealing the potential of both PermeaDerm C and PermeaDerm A to promote effective healing while preventing excessive scar formation.
- Subjects
WOUND healing; POROSITY; SALINOMYCIN; HEALING; CHRONIC wounds &; injuries
- Publication
ePlasty: Open Access Journal of Plastic Surgery, 2018, Vol 18, p177
- ISSN
1937-5719
- Publication type
Article