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- Title
Phosphaturic Mesenchymal Tumors with or without Phosphate Metabolism Derangements.
- Authors
Montanari, Andrea; Pirini, Maria Giulia; Lotrecchiano, Ludovica; Di Prinzio, Lorenzo; Zavatta, Guido
- Abstract
Phosphaturic mesenchymal tumors (PMT) are rare neoplasms, which can give rise to a multifaceted syndrome, otherwise called tumor-induced osteomalacia (TIO). Localizing these tumors is crucial to obtain a cure for the phosphate metabolism derangement, which is often the main cause leading the patient to seek medical help, because of invalidating physical and neuromuscular symptoms. A proportion of these tumors is completely silent and may grow unnoticed, unless they become large enough to produce pain or discomfort. FGF-23 can be produced by several benign or malignant PMTs. The phosphate metabolism, radiology and histology of these rare tumors must be collectively assessed by a multidisciplinary team aimed at curing the disease locally and improving patients' quality of life. This narrative review, authored by multiple specialists of a tertiary care hospital center, will describe endocrine, radiological and histological features of these tumors, as well as present surgical and interventional strategies to manage PMTs.
- Subjects
PHOSPHATE metabolism; OSTEOMALACIA; TUMORS; HELP-seeking behavior; TERTIARY care
- Publication
Current Oncology, 2023, Vol 30, Issue 8, p7478
- ISSN
1198-0052
- Publication type
Article
- DOI
10.3390/curroncol30080541