We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Characteristics of Protooncogene Expression in A5 Cells.
- Authors
Kousvelari, Elini; Yeh, Chih-Ko
- Abstract
Stimulation of β-adrenergic receptors by isoproterenol or addition of 8-BrcAMP rapidly and transiently induces the expression of the protooncogenes, c-fos, and jun B, but not that of c-jun in A5 cells. These results indicate that different intracellular pathways may operate within the same cell for the induction of this group of early response genes. The inducibility of c-fos and jun B genes by either isoproterenol of 8-BrcAMP is transcriptionally regulated and accompanied by increases in their respective products. Furthermore, both c-fos and jun B mRNA levels are elevated at G0G1 phase of the A5 cell cycle and are inducible by isoproterenol or 8-BrcAMP at the different phases of the cell cycle. These data further suggest a possible role of c-fos and jun B in A5 cell cycle.
- Subjects
PROTO-oncogenes; ADRENERGIC receptors; BIOLOGICAL rhythms; BRONCHODILATOR agents; ISOPROTERENOL; CELL cycle; AMINOBENZYL alcohol; ISOPROPYLAMINE; SYMPATHOMIMETIC agents; MESSENGER RNA; CANCER genes
- Publication
Critical Reviews in Oral Biology & Medicine, 1993, Vol 4, Issue 3, p531
- ISSN
1045-4411
- Publication type
Article
- DOI
10.1177/10454411930040033901