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- Title
Lipoprotein(a) and coronary artery disease in Chinese postmenopausal female patients: a large cross-sectional cohort study.
- Authors
Shuo-Lin Liu; Na-Qiong Wu; Yuan-Lin Guo; Cheng-Gang Zhu; Ying Gao; Jing Sun; Rui-Xia Xu; Geng Liu; Qian Dong; Jian-Jun Li; Liu, Shuo-Lin; Wu, Na-Qiong; Guo, Yuan-Lin; Zhu, Cheng-Gang; Gao, Ying; Sun, Jing; Xu, Rui-Xia; Liu, Geng; Dong, Qian; Li, Jian-Jun
- Abstract
<bold>Background: </bold>It has been reported that lipoprotein(a) (Lp(a)) is associated with the risk of cardiovascular disease. The present study aimed to examine the association of Lp(a) levels with the presence and severity of coronary artery disease (CAD) in female patients.<bold>Methods: </bold>A total of 3712 female patients who received coronary angiography were consecutively enrolled. The levels of Lp(a) were measured and compared among patients with or without CAD, myocardial infarction and menopause. Spearman correlation analysis and logistic regression analysis were used to examine the association of Lp(a) with the presence of CAD and the severity of coronary atherosclerosis assessed by Gensini score (GS).<bold>Results: </bold>The average of Lp(a) levels was elevated as age increased in female subjects. Notably, women after menopause had higher Lp(a) levels compared with that before menopause (16.8 mg/dL (IQR 7.54-41.12 mg/dL) vs 14.7 mg/dL (IQR 6.72-30.82 mg/dL), p=0.002). Furthermore, multiple logistic regression analysis identified that Lp(a)>30 mg/dL was an independent risk factor of CAD in the postmenopausal females (OR: 1.33, 95% CI: 1.08 to 1.63, p=0.007). Finally, Lp(a) had a positive correlation with GS (r=0.11, p<0.001), and Lp(a)>30 mg/dL was an independent risk factor for high GS (OR: 1.43, 95% CI: 1.14 to 1.79, p=0.02) in the postmenopausal females.<bold>Conclusion: </bold>Circulating Lp(a) levels were independently associated with the presence and severity of CAD in the postmenopausal females, suggesting that Lp(a) may be useful for prevention and risk-stratification of CAD in female individuals.
- Subjects
CHINA; CORONARY disease; DYSLIPIDEMIA; WOMEN patients; HORMONE therapy for menopause; STRESS echocardiography; CARDIOVASCULAR diseases risk factors; LIPOPROTEINS; AGE distribution; CROSS-sectional method; SEVERITY of illness index; CORONARY angiography; POSTMENOPAUSE; LONGITUDINAL method
- Publication
Postgraduate Medical Journal, 2019, Vol 95, Issue 1128, p534
- ISSN
0032-5473
- Publication type
journal article
- DOI
10.1136/postgradmedj-2019-136591